Ukwakheka kwe-thrombus kuhlobene nokulimala kwe-vascular endothelial, i-hypercoagulability yegazi, nokuhamba kancane kwegazi.Ngakho-ke, abantu abanalezi zici ezintathu zobungozi bathambekele ku-thrombus.

1. Abantu abanokulimala kwe-vascular endothelial, njengalabo abaye babhoboza i-vascular, i-catheterization ye-venous, njll., ngenxa ye-endothelium ye-vascular eyonakele, ama-collagen fibers adalulwe ngaphansi kwe-endothelium angenza kusebenze ama-platelet nezici ze-coagulation, ezingase ziqalise ukuhlangana kwe-endogenous.Isistimu ibangela i-thrombosis.

2. Abantu abagazi labo lisesimeni esinamandla kakhulu, njengeziguli ezinezimila eziyingozi, i-systemic lupus erythematosus, ukuhlukumezeka okukhulu noma ukuhlinzwa okukhulu, banezici eziningi zokujiya egazini labo futhi maningi amathuba okuthi bajiye kunegazi elivamile, ngakho-ke maningi amathuba okuba bahlangane. ukwakha i-thrombosis.Esinye isibonelo ngabantu abathatha izinto zokuvimbela inzalo, i-estrogen, i-progesterone nezinye izidakamizwa isikhathi eside, umsebenzi wabo we-coagulation wegazi nawo uzothinteka, futhi kulula ukwenza amahlule egazi.

3. Abantu abagazi labo lihamba kancane, njengalabo abahlala bathule isikhathi eside bedlala i-mahjong, babukele i-TV, bafunde, bathathe isigaba sezomnotho, noma bahlale embhedeni isikhathi eside, ukuntuleka kokuzivocavoca umzimba kungabangela ukugeleza kwegazi ukunciphisa ijubane noma ngisho nokuma Ukwakheka kwama-vortices kubhubhisa isimo esivamile sokugeleza kwegazi, okuzokwandisa ithuba lamaplatelet, amangqamuzana e-endothelial kanye nezici ze-coagulation ukuxhumana, futhi kulula ukwakha i-thrombus.