I-Thrombin ingakhuthaza ukuhlangana kwegazi, ibambe iqhaza ekunqandeni ukopha, futhi ingakhuthaza ukuphulukiswa kwesilonda kanye nokulungiswa kwezicubu.

I-Thrombin iyi-enzyme ebalulekile enqubweni yokuhlangana kwegazi, futhi iyi-enzyme eyinhloko eyaguqulwa ekuqaleni yaba i-fibrin ku-fibrin.Lapho imithambo yegazi yonakele, i-glycrase ikhiqizwa ngaphansi kwesenzo samaplatelet kanye namaseli e-vascular endothelial, okuthuthukisa ukuhlangana kweplatelet kanye ne-thrombosis, ngaleyo ndlela kumise i-hemostasis.Ngaphezu kwalokho, i-coordinase ingaphinde ikhuthaze ukuphulukiswa kwesilonda kanye nokulungiswa kwezicubu, okuyisithako esibalulekile se-enzyme ekulungiseni izicubu.

Kufanele kuqashelwe ukuthi ukusebenza ngokweqile kwe-thrombin kungase futhi kubangele izinkinga ezifana ne-thrombosis nesifo senhliziyo.Ngakho-ke, kuyadingeka ukulandela ngokuqinile iseluleko sikadokotela kanye nomthamo wezidakamizwa lapho usebenzisa izidakamizwa ezihlobene ne-coordinase ukuze ugweme ukusabela okubi nemiphumela emibi.

Umsebenzi we-fibrinogen ekuqaleni wawuwumphumela wokukhuthaza ukuhlangana kweplatelet ekuhlanganiseni kwegazi.I-Fibrinogen ekuqaleni yayiyiprotheni ebalulekile enqubweni ye-coagulation.Umsebenzi wayo oyinhloko ukuhlangana kanye ne-hemostasis, nokubamba iqhaza ekukhiqizeni ama-platelet.Inani elivamile le-fibrinogen ngu-2-4g/L.Ukuphakama kwezinga lokuqala le-fibrin kuhlobene eduze nokuvela kwezifo ze-thrombotic.Ukukhuphuka kokukhuphuka kwe-fibrin kungase kubangelwe izici zomzimba, njengokukhulelwa sekwephuzile kanye neminyaka yobudala, noma izici ze-pathological, ezifana nomfutho wegazi ophezulu, isifo sikashukela, isifo senhliziyo se-coronary atherosclerotic.

Izinga le-fibrin liyancipha, elingase libangelwe izifo zesibindi, njenge-cirrhosis nesifo sokusha kwesibindi esinamandla.Iziguli kudingeka ziye esibhedlela ukuze ziyohlolwa kusenesikhathi futhi zelaphe ngaphansi kokuqondisa kukadokotela.