Ukubaluleka komtholampilo
Ngokuyisisekelo inencazelo efanayo nesikhathi sokuhlangana, kodwa ngokuzwela okuphezulu.Iningi lezindlela zokunquma ze-APTT ezisetshenziswayo njengamanje zingaba ezingavamile lapho isici se-plasma coagulation singaphansi kuka-15% kuya ku-30% wezinga elivamile.
(1) Ukwelulwa kwe-APTT: umphumela we-APTT umude ngamasekhondi ayi-10 kunalowo wokulawula okuvamile.I-APTT ukuhlolwa kokuhlola okuthembeke kakhulu kokushoda kwe-endogenous coagulation factor futhi isetshenziswa kakhulu ukuthola i-hemophilia ethambile.Nakuba isici Ⅷ: Amazinga C angatholwa ngaphansi kuka-25% we-hemophilia A, ukuzwela ku-subclinical hemophilia (isici Ⅷ>25%) kanye nabathwali be-hemophilia kubi.Imiphumela ende ibonakala ku-factor Ⅸ (hemophilia B), Ⅺ kanye Ⅶ ukusilela;lapho izinto ze-anticoagulant zegazi ezifana ne-coagulation factor inhibitors noma amazinga e-heparin enyuka, i-prothrombin, i-fibrinogen ne-factor V, ukuntuleka kwe-X nakho Kungaqhubeka isikhathi eside, kodwa ukuzwela kuyancipha kancane;Ukwelulwa kwe-APTT kungabonakala nakwezinye iziguli ezinesifo sesibindi, i-DIC, nenani elikhulu legazi eligcinwe ebhange.
(2) Ukufinyeza kwe-APTT: kubonakala ku-DIC, isimo se-prethrombotic kanye nesifo se-thrombotic.
(3) Ukuqapha ukwelashwa kwe-heparin: I-APTT izwela kakhulu ekugxilweni kwe-plasma heparin, ngakho-ke iyinkomba yokuqapha ilabhorethri esetshenziswa kabanzi njengamanje.Ngalesi sikhathi, kufanele kuqashelwe ukuthi umphumela wokulinganisa we-APTT kufanele ube nobudlelwano obuqondile ne-plasma ye-heparin ebangeni lokwelapha, ngaphandle kwalokho akufanele isetshenziswe.Ngokuvamile, ngesikhathi sokwelashwa nge-heparin, kuyatuseka ukuthi i-APTT igcinwe izikhathi ezi-1.5 kuye kwezingu-3.0 zokulawula okujwayelekile.
Ukuhlaziywa kwemiphumela
Ngokomtholampilo, i-APTT ne-PT zivame ukusetshenziswa njengokuhlola umsebenzi wokuhlangana kwegazi.Ngokwemiphumela yokulinganisa, cishe kunezimo ezine ezilandelayo:
(1) Kokubili i-APTT ne-PT kuvamile: Ngaphandle kwabantu abavamile, ibonakala kuphela ekuntuleni kofuzo kanye nesesibili kwe-FXIII.Ezitholiwe zivamile ezifweni ezinzima zesibindi, isimila sesibindi, i-lymphoma eyingozi, i-leukemia, i-anti-factor XIII antibody, i-autoimmune anemia kanye ne-anemia eyingozi.
(2) I-APTT ende ene-PT evamile: Iningi lezinkinga zokopha zibangelwa ukukhubazeka endleleni ye-intrinsic coagulation.Okufana ne-hemophilia A, B, kanye nokuntuleka kwesici Ⅺ;kukhona ama-anti-factor Ⅷ, Ⅸ, Ⅺ amasosha omzimba ekuhambeni kwegazi.
(3) I-APTT Evamile ene-PT ende: izinkinga eziningi zokopha okubangelwa ukukhubazeka kumzila we-coagulation wangaphandle, njengokuntuleka kofuzo kanye nokutholwa kwe-Factor VII.Ezitholiwe zivamile ezifweni zesibindi, i-DIC, ama-anti-factor VII amasosha omzimba ekujikelezeni kwegazi kanye nama-anticoagulants omlomo.
(4) Kokubili i-APTT ne-PT ziqhubeka isikhathi eside: izifo eziningi zokopha ezibangelwa ukukhubazeka endleleni evamile yokuhlanganisa, njengofuzo kanye nokuntuleka kwe-factor X, V, II kanye ne-I.Ezitholiwe zibonakala ikakhulukazi ezifweni zesibindi kanye ne-DIC, futhi izici X no-II zingancishiswa lapho kusetshenziswa ama-anticoagulants omlomo.Ukwengeza, uma kukhona amasosha omzimba e-anti-factor X, anti-factor V kanye ne-anti-factor II ekuhambeni kwegazi, nawo anda isikhathi eside ngokufanele.Lapho i-heparin isetshenziswa emtholampilo, zombili i-APTTT ne-PT zinwetshwa ngokufanele.