I-FIB isifinyezo sesiNgisi se-fibrinogen, futhi i-fibrinogen iyisici sokuhlangana.I-high blood coagulation ye-FIB value isho ukuthi igazi lisesimweni se-hypercoagulable, futhi i-thrombus yakheka kalula.
Ngemva kokuqaliswa komshini wokuhlangana komuntu, i-fibrinogen iba i-fibrin monomer ngaphansi kwesenzo se-thrombin, futhi i-fibrin monomer inganqwabelana ibe yi-fibrin polymer, ewusizo ekwakhekeni kwehlule legazi futhi idlala indima ebalulekile enqubweni yokuhlangana.
I-Fibrinogen ikhiqizwa ikakhulukazi ama-hepatocyte futhi iyiprotheni esebenza ngokuhlangana.Inani layo elivamile liphakathi kuka-2~4qL.I-Fibrinogen iyinto ehlobene ne-coagulation, futhi ukwanda kwayo kuvame ukusabela okungaqondile komzimba futhi kuyisici esiyingozi sezifo ezihlobene ne-thromboembolism.
I-Coagulation FIB value ingakhuphuka ezifweni eziningi, izici ezivamile zofuzo noma ukuvuvukala, i-lipids ephezulu yegazi, umfutho wegazi
Isifo senhliziyo, isifo sikashukela, isifo sofuba, isifo sezicubu ezixhumeneyo, isifo senhliziyo, nezimila ezimbi.lapho uhlushwa yizo zonke izifo ezingenhla kungase kuholele ekuveleni kwamahlule egazi.Ngakho-ke, i-high blood coagulation ye-FIB value ibhekisela esimweni sokuhlangana kwegazi eliphezulu.
Izinga eliphezulu le-fibrinogen lisho ukuthi igazi lisesimweni se-hypercoagulability futhi livame ukuba ne-thrombosis.I-Fibrinogen yaziwa nangokuthi i-coagulation factor I. Noma ngabe i-endogenous coagulation noma i-exogenous coagulation, isinyathelo sokugcina se-fibrinogen sizokwenza i-fibroblasts isebenze.Amaprotheni ahlanganiswa kancane kancane abe yinethiwekhi ukuze enze amahlule egazi, ngakho-ke i-fibrinogen imele ukusebenza kwe-blood coagulation.
I-Fibrinogen ikhiqizwa ikakhulukazi isibindi futhi ingakhuphuka ezifweni eziningi.Izici ezivamile zofuzo noma ukuvuvukala zihlanganisa high blood lipids, high blood pressure, coronary heart disease, diabetes, tuberculosis, connective tissue disease, isifo senhliziyo, futhi Amathumba ayingozi azovuka.Ngemuva kokuhlinzwa okukhulu, ngenxa yokuthi umzimba udinga ukwenza umsebenzi we-hemostasis, uzophinde ukhuthaze ukwanda kwe-fibrinogen yomsebenzi we-hemostasis.
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