I-APTT isifinyezo sesiNgisi sesikhathi se-prothrombin esicushwe kancane.I-APTT ukuhlolwa kokuhlola okubonisa indlela ye-endogenous coagulation.I-APTT ende ibonisa ukuthi into ethile yokuhlangana kwegazi ehilelekile endleleni ye-endogenous coagulation yabantu ayisebenzi.Ngemuva kokuthi i-APTT isinde, isiguli sizoba nezimpawu ezisobala zokopha.Ngokwesibonelo, iziguli ezine-hemophilia A, i-hemophilia B, kanye nesifo sika-von Willebrand zonke zizoba ne-APTT ende, futhi isiguli siyoba ne-ecchymosis esikhumbeni nolwelwesi lwamafinyila, nokopha kwemisipha., ukopha okuhlangene, i-hematoma, njll. Ikakhulukazi ezigulini ezine-hemophilia A, ukukhubazeka okuhlangene kanye ne-muscle atrophy ngokuvamile kushiywa ngemva kokuba i-hematoma idonswe ngenxa ye-synovitis ebangelwa ukopha okuhlangene, okunomthelela omkhulu empilweni.Ngaphezu kwalokho, ukusabalalisa kwe-intravascular coagulation, isifo sesibindi esibi kanye nezinye izifo kuzophinde kubangele ukwanda okuphawulekayo kwe-APTT, okuzodala ukulimala okusobala emzimbeni womuntu.
Inani eliphakeme le-Apt libonisa ukuthi isiguli singase sibe nezinkinga zokopha.Izifo ezivamile zokopha zihlanganisa ukusweleka kwe-congenital coagulation factor kanye ne-hemophilia.Okwesibili, kusolwa ukuthi kubangelwa isifo sesibindi noma i-jaundice evimbelayo noma isifo se-thrombotic.Akushiwo futhi ukuthi kubangelwa ithonya lezici zezidakamizwa, njengokusetshenziswa isikhathi eside kwezidakamizwa ze-anticoagulant.Ngokomtholampilo, ukuhlolwa kwe-apt kungasetshenziselwa ukwahlulela ukuthi umsebenzi wokuhlangana emzimbeni wesiguli ujwayelekile yini.Uma kungenxa yento ebangelwa i-hemophilia, kunconywa ukuthi ulandele iseluleko sikadokotela sokuyeka ukuphuma kwegazi noma ukusebenzisa i-prothrombin yokwelashwa okuyinkimbinkimbi.