Imbangela eyisisekelo

1. Ukulimala kwe-cardiovascular endothelial
Ukulimala kwe-vascular endothelial cell kuyimbangela ebaluleke kakhulu futhi evamile yokwakheka kwe-thrombus, futhi kuvame kakhulu ku-endocarditis ye-rheumatic ne-infective, izilonda ezinzima ze-atherosclerotic plaque, amasayithi okulimala kwe-arteriovenous ebuhlungu noma evuthayo, njll. Kukhona futhi i-hypoxia, ukushaqeka, i-sepsis kanye nebhaktheriya. ama-endotoxins abangela izifo eziningi ezingapheli emzimbeni wonke.
Ngemuva kokulimala kwesikhumba, i-collagen engaphansi kwe-endothelium yenza kusebenze inqubo ye-coagulation, ibangele ukusabalalisa kwe-intravascular coagulation, kanye namafomu e-thrombus ku-microcirculation yomzimba wonke.

2. Ukugeleza kwegazi okungavamile
Ngokuyinhloko ibhekisela ekunciphiseni ukugeleza kwegazi kanye nokukhiqizwa kwama-eddies ekugelezeni kwegazi, njll., futhi izici ezicushiwe zokuhlanganisa kanye ne-thrombin zifinyelela ekugxilweni okudingekayo ukuze kuhlanganiswe endaweni yendawo, okulungele ukwakheka kwe-thrombus.Phakathi kwabo, i-veins ijwayele kakhulu i-thrombus, evame kakhulu ezigulini ezinesifo senhliziyo, ukugula okungapheli kanye nokuphumula kombhede ngemuva kokuhlinzwa.Ngaphezu kwalokho, ukugeleza kwegazi enhliziyweni nasemithanjeni kuyashesha, futhi akulula ukwenza i-thrombus.Kodwa-ke, lapho ukugeleza kwegazi ku-atrium yangakwesobunxele, i-aneurysm, noma igatsha lomkhumbi wegazi kuhamba kancane futhi i-eddy current yenzeka ngesikhathi se-mitral valve stenosis, iphinde ibe sengozini ye-thrombosis.

3. Ukwanda kwe-coagulation yegazi
Ngokuvamile, ama-platelet kanye nezici ze-coagulation egazini zanda, noma umsebenzi we-fibrinolytic system wehla, okuholela esimweni se-hypercoagulable egazini, esivame kakhulu ezimweni ze-hypercoagulable ne-hereditary.

4. I-Hereditary hypercoagulable state
Ihlobene ne-hereditary coagulation factor defects, ukukhubazeka kokuzalwa kweprotheni C kanye ne-protein S, njll. Phakathi kwabo, isici esivame kakhulu ukuguqulwa kofuzo lwe-V, izinga lokuguqulwa kwalesi sakhi sofuzo lingafinyelela ku-60% ezigulini ezine-thrombosis ejulile ye-vein thrombosis.

5. Kutholwe isimo se-hypercoagulable
Okuvame ukubonakala kumdlavuza we-pancreatic, umdlavuza wamaphaphu, umdlavuza webele, umdlavuza we-prostate, umdlavuza wesisu kanye nezinye izimila ezimbi ezithuthukisiwe ze-metastatic, ezibangelwa ukukhululwa kwezici ze-procoagulant ngamaseli omdlavuza;kungase futhi kwenzeke ekuhlukumezeni okukhulu, ukushisa okukhulu, ukuhlinzwa okukhulu noma ngemva kokubeletha Uma kwenzeka ukulahlekelwa igazi elikhulu, futhi ezimweni ezifana nomfutho wegazi ophakeme wokukhulelwa, i-hyperlipidemia, i-coronary atherosclerosis, ukubhema, nokukhuluphala.