I-Thrombosis yinqubo lapho igazi eligelezayo lihlangana khona futhi liphenduke libe yihlule legazi, njenge-cerebral artery thrombosis (okubangela i-cerebral infarction), i-vein thrombosis ejulile yemikhawulo engezansi, njll. Ihlule legazi elakhiwe yi-thrombus;ihlule legazi elakheke engxenyeni ethile yomkhumbi wegazi liyahamba ligudle umgudu wegazi futhi livalelwe komunye umthambo wegazi.Inqubo ye-embolization ibizwa ngokuthi i-embolism.I-deep vein thrombosis yemilenze engezansi iyawa, ifuduke, futhi ivalelwe emthanjeni we-pulmonary futhi ibangele i-pulmonary embolism.;Ihlule legazi elibangela i-embolism libizwa ngokuthi i-embolus ngalesi sikhathi.
Ekuphileni kwansuku zonke, ihlule legazi likhishwa ngemva kokumiswa kwe-nosebleed;lapho kulimale khona ukulimala, ngezinye izikhathi kungase kuzwakale isigaxa, okuyi-thrombus;futhi i-myocardial infarction ibangelwa ukuphazamiseka kokugeleza kwegazi lapho umthambo wegazi ovimbela inhliziyo uvinjwa ihlule legazi I-Ischemic necrosis ye-myocardium.
Ngaphansi kwezimo zomzimba, indima ye-thrombosis ukumisa ukopha.Ukulungiswa kwanoma yiziphi izicubu nezitho kufanele kuqale kumise ukopha.I-Hemophilia i-coagulopathy ebangelwa ukuntuleka kwezinto ezihlangene.Kunzima ukwenza i-thrombus engxenyeni elimele futhi ayikwazi ukumisa ngokuphumelelayo ukopha futhi kubangele ukopha.Iningi le-hemostatic thrombosis lakha futhi likhona ngaphandle kwesitsha segazi noma lapho isitsha segazi siphukile.
Uma ihlule legazi lakheka emithanjeni yegazi, ukugeleza kwegazi emithanjeni yegazi kuyavaleka, ukugeleza kwegazi kuyehla, noma ngisho nokugeleza kwegazi kuyaphazamiseka.Uma i-thrombosis yenzeka emithanjeni, izobangela i-ischemia yesitho/izicubu ngisho ne-necrosis, njenge-myocardial infarction, i-cerebral infarction, kanye ne-necrosis/ukunqunywa komkhawulo ophansi.I-thrombus eyakhiwe emithanjeni ejulile yamaphethelo aphansi ayithinti nje kuphela ukugeleza kwegazi le-venous enhliziyweni futhi ibangele ukuvuvukala kwamaphethelo aphansi, kodwa futhi iwela nge-vena cava engaphansi, i-atrium yangakwesokudla kanye ne-ventricle yangakwesokudla ukuze ingene futhi ivalele ngaphakathi. i-pulmonary artery, okuholela embolism yamaphaphu.Izifo ezinamazinga aphezulu okufa.
Ukuqala kwe-thrombosis
Ezimweni eziningi, isixhumanisi sokuqala se-thrombosis siwukulimala, okungaba ukuhlukumezeka, ukuhlinzwa, ukuphuka kwe-plaque emithanjeni, noma ngisho nokulimala kwe-endothelial okubangelwa ukutheleleka, ukuzivikela komzimba nezinye izici.Le nqubo yokwakheka kwe-thrombus eqalwa ukulimala ibizwa ngokuthi i-exogenous coagulation system.Ezimweni ezimbalwa, ukuqina kwegazi noma ukuncipha kokugeleza kwegazi kungase futhi kuqalise inqubo ye-thrombosis, okuyindlela yokwenza kusebenze ukuxhumana, okubizwa ngokuthi i-endogenous coagulation system.
I-hemostasis eyinhloko
Uma ukulimala kuthinta imithambo yegazi, ama-platelet aqale abambelele ukuze akhe ungqimba olulodwa lokuvala isilonda, abese ecushwa ukuze ahlanganiswe ukuze akhe ama-clumps, okuyi-platelet thrombi.Yonke le nqubo ibizwa ngokuthi i-primary hemostasis.
I-hemostasis yesibili
Ukulimala kukhipha into ebizwa ngokuthi yi-tissue factor, eqala uhlelo lwe-endogenous coagulation ukukhiqiza i-thrombin ngemva kokungena egazini.I-Thrombin empeleni iyisisusa esishintsha iphrotheni ehlanganayo egazini, okungukuthi, i-fibrinogen ibe yi-fibrin., Yonke le nqubo ibizwa ngokuthi i-hemostasis yesibili.
"Ukusebenzelana Okuphelele"I-Thrombosis
Ngenqubo ye-thrombosis, isigaba sokuqala se-hemostasis (i-platelet adhesion, activation and aggregation) kanye nesigaba sesibili se-hemostasis (ukukhiqizwa kwe-thrombin nokwakheka kwe-fibrin) kuyasebenzisana.I-hemostasis yesigaba sesibili ingenziwa kuphela ngokujwayelekile lapho kukhona ama-platelet, futhi i-thrombin eyakhiwe iphinde isebenze ama-platelet.Laba bobabili basebenza ndawonye futhi basebenzisane ukuze baqedele inqubo ye-thrombosis.
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