Inqubo ye-thrombosis, kufaka phakathi izinqubo ezi-2:

1. Ukunamathela kanye nokuhlanganiswa kwamaplatelet egazini

Esigabeni sokuqala se-thrombosis, ama-platelet adonswa ngokuqhubekayo ukusuka ekugelezeni kwe-axial futhi anamathele ebusweni bemicu ye-collagen edaluliwe ku-intima yemithambo yegazi eyonakele.Ama-platelet acushwa yi-collagen futhi akhulule izinto ezifana ne-ADP, i-thromboxane A2, i-5-AT ne-platelet factor IV., Lezi zinto zinomthelela oqinile we-agglutinating platelet, ukuze ama-platelet egazini aqhubeke enqwabelana endaweni ukuze akhe inqwaba ye-platelet emise okwendunduma., ukuqala kwe-venous thrombosis, ikhanda le-thrombus.

Ama-platelets anamathela ebusweni bemicu ye-collagen eveziwe ku-intima yomkhumbi wegazi owonakele futhi acushiwe ukuze akhe isitaki seplatelet esifana ne-hillock.I-hillock ikhula kancane kancane futhi ixubane ne-leukocyte ukuze yenze i-thrombus emhlophe.Inama-leukocyte amaningi anamathele ebusweni bayo.Ukugeleza kwegazi kuncipha kancane kancane, i-coagulation system iyasebenza, futhi inani elikhulu le-fibrin lakha isakhiwo senethiwekhi, esibamba amangqamuzana egazi abomvu engeziwe namangqamuzana egazi amhlophe ukuze akhe i-thrombus exubile.

2. Ukujiya kwegazi

Ngemva kokwakhiwa kwe-thrombus emhlophe, iphumela ku-lumen ye-vascular, okwenza ukuthi ukugeleza kwegazi ngemuva kwayo kunciphe futhi kuvele i-whirlpool, futhi i-platelet indunduma entsha yakheka ku-whirlpool.I-Trabeculae, emise okwe-coral, inama-leukocyte amaningi anamathele ebusweni bawo.

Ukugeleza kwegazi phakathi kwe-trabeculae kuncipha kancane kancane, uhlelo lwe-coagulation lucushiwe, futhi ukugxila kwezici ze-coagulation zendawo kanye nezici ze-platelet kuyanda kancane kancane, okwenza futhi kuhlanganiswe kusakhiwo se-mesh phakathi kwe-trabeculae.I-thrombus exubene emhlophe nemhlophe eyakha umzimba we-thrombus.

I-thrombus exutshwe kancane kancane yanda futhi yanwetshwa ohlangothini lokugeleza kwegazi, futhi ekugcineni yavimba ngokuphelele i-lumen yomkhumbi wegazi, okwenza ukugeleza kwegazi kume.