Abacwaningi baseMonash University baklame i-antibody entsha engavimbela iphrotheni ethile egazini ukuvimbela i-thrombosis ngaphandle kwemiphumela emibi engaba khona.Le antibody ingavimbela i-thrombosis ye-pathological, engabangela ukuhlaselwa yinhliziyo nokushaywa unhlangothi ngaphandle kokuphazamisa umsebenzi ojwayelekile wokuvala igazi.

Ukuhlaselwa yinhliziyo nokushaywa unhlangothi kuseyimbangela ehamba phambili yokushona kwabantu kanye nezifo emhlabeni wonke.Imithi yamanje ye-antithrombotic (anticoagulant) ingabangela futhi ibangele izinkinga ezinkulu zokopha ngoba futhi iphazamisa ukujiyisa kwegazi okuvamile.Iziguli ezine kwezinhlanu ezithola ukwelashwa kwe-antiplatelet zisenezehlakalo zenhliziyo nemithambo yegazi eziphindaphindayo.

Ngakho-ke, izidakamizwa ezikhona ze-antiplatelet azikwazi ukusetshenziswa ngemithamo emikhulu.Ngakho-ke, ukusebenza kahle komtholampilo kusadumaza, futhi ukwelashwa kwesikhathi esizayo kudinga ukuklanywa kabusha ngokuyisisekelo.

Indlela yocwaningo eyokuqala inqume umehluko webhayoloji phakathi kokuhlangana okujwayelekile kanye ne-pathological coagulation, futhi uthole ukuthi i-von Willebrand factor (VWF) ishintsha izici zayo lapho i-thrombus eyingozi kwakheka.Ucwaningo luklame i-antibody ethola futhi ivimbe kuphela lolu hlobo lwe-VWF lwe-pathological, ngoba lusebenza kuphela lapho ihlule legazi liba yi-pathological.

Ucwaningo luhlaziye izici zamasotsha omzimba akhona alwa ne-VWF futhi lwanquma izici ezingcono kakhulu ze-antibody ngayinye ukuze zibophe futhi zivimbe i-VWF ngaphansi kwezimo ze-pathological coagulation.Uma kungekho ukusabela okubi, lamasosha omzimba angaba khona aqale ahlanganiswe abe isakhiwo esisha segazi ukuvimbela lezi zinkinga ezingaba khona.

Odokotela njengamanje babhekene nebhalansi ebucayi phakathi kokusebenza kwezidakamizwa kanye nemiphumela engemihle yokopha.I-antibody eyenziwe ngobunjiniyela iklanywe ngokukhethekile futhi ngeke iphazamise ukuhlangana kwegazi okuvamile, ngakho-ke kwethenjwa ukuthi ingasebenzisa umthamo ophezulu futhi osebenza kangcono kunezokwelapha ezikhona.

Lolu cwaningo lwe-in vitro lwenziwa ngamasampula egazi lomuntu.Isinyathelo esilandelayo ukuhlola ukusebenza kahle kwe-antibody kumodeli yesilwane esincane ukuze uqonde ukuthi isebenza kanjani ohlelweni lokuphila oluyinkimbinkimbi olufana nolwethu.

Inkomba: Thomas Hoefer et al.Ithagethi ye-shear gradient yenziwe yasebenza i-von Willebrand factor ngenoveli ye-single-chain antibody A1 inciphisa ukwakheka kwe-occlusive thrombus in vitro, Haematologica (2020).