Ukuphazamiseka kokujiya kwegazi kuyingozi empilweni, ngoba ukuphazamiseka kwe-coagulation kungenxa yezizathu ezahlukahlukene ezibangela ukuphazamiseka kokusebenza komzimba womuntu.Ngemuva kokungasebenzi kahle kwe-coagulation, uchungechunge lwezimpawu zokuphuma kwegazi luzokwenzeka.Uma kwenzeka ukopha okukhulu kwe-intracranial, kunengozi enkulu yokuphila.Ngenxa yokuthi kunezifo eziningi ezibangelwa ukungasebenzi kahle kwe-coagulation, umtholampilo ovame kakhulu i-hemophilia A, i-hemophilia B, i-vascular hemophilia, ukushoda kwe-vitamin K, ukusabalalisa imithambo yegazi kuvithamini Lezi zifo zingabangela izifo ezingasebenzi kahle.Uma kuyisiguli esine-hemophilia A enamandla, kunokuthambekela kokopha okusobala ngokwakho.Ngemuva kokuhlukumezeka okuncane, kulula ukubangela ukopha.Uma iziguli ezine-hemophilia A enzima zihlushwa ukuhlukumezeka, kulula ukubangela ukopha okukhulu kwe-craniocerebral, okubeka impilo yesiguli engozini.Ngaphezu kwalokho, kanzima kwangaphakathi imithambo yegazi coagulation, ngenxa ukusetshenziswa kanye coagulation ukungasebenzi izici ezihlukahlukene coagulation, futhi othambekele ukopha kakhulu, okuholela ekufeni zakuqala isiguli.