Iziyaluyalu ze-coagulation ziyingozi empilweni, ngoba ukuphazamiseka kwe-coagulation kungenxa yezizathu ezihlukahlukene ezenza umsebenzi womzimba womuntu uphazamiseke.Ngemuva kokungasebenzi kahle kwe-coagulation, umzimba womuntu uzovela uchungechunge lwezimpawu zokopha.Uma kwenzeka ukopha okukhulu kwe-intracranial, kuyingozi kakhulu empilweni.Ngenxa yokuthi ukungasebenzi kahle kwe-coagulation kungabangelwa izifo ezihlukahlukene, ukushoda kwe-vitamin K okuvame kakhulu emtholampilo, ukusatshalaliswa kwe-intravascular coagulation, isifo sesibindi esinzima, i-hemophilia a, i-hemophilia b, isifo se-von Willebrand, njll. Ukuphazamiseka kokuxhuma kungenzeka kulezi zifo.

Uma kuyisiguli esine-hemophilia A enzima, sinokuthambekela okusobala kokopha, futhi kulula ukuheha ukopha ngemva kokuhlukumezeka okuncane.Uma isiguli esine-hemophilia A enzima sibhekana nokuhlukumezeka, kulula ukubangela ukopha okukhulu ebuchosheni, okufaka impilo yesiguli engozini.Ngaphezu kwalokho, i-coagulation esakazwa kakhulu ye-intravascular coagulation nayo ijwayele ukopha kakhulu ngenxa yokusetshenziswa kwezinto ezihlukahlukene ze-coagulation kanye nokungasebenzi kahle kwe-coagulation, okuholela ekufeni kweziguli kusenesikhathi.