Lapho ukungasebenzi kahle kwe-coagulation kwesiguli kuholela ekopheni, kungase kubangelwe ukwehla kokusebenza kokujiya.Kudingeka ukuhlolwa kwe-coagulation factor.Kuyacaca ukuthi ukopha kubangelwa ukungabi bikho kwezici ze-coagulation noma izici eziningi ze-anticoagulation.Ngokwembangela, yengeza izici ezihambisanayo zokuhlangana noma i-plasma entsha.Ukuba khona kwezinto ezijiyisa kakhulu kungasiza ukuyeka ukopha.Ngokomtholampilo, kungatholwa ukuthi izici ezihambisanayo zokuhlangana kwezindlela zangaphakathi nezangaphandle ze-coagulation umsebenzi we-coagulation ziyancishiswa noma zinokungasebenzi kahle, futhi uhlole ukuthi umsebenzi we-coagulation ongavamile ubangelwa ukuntuleka kwezinto ezihlangene noma umsebenzi we-coagulation factor, ikakhulukazi. okuhlanganisa lezi zimo ezilandelayo:

1. Indlela ye-endogenous coagulation engavamile: Isici esiyinhloko sokuhlangana esithinta indlela ye-endogenous coagulation yi-APTT.Uma i-APTT ithatha isikhathi eside, kusho ukuthi kunezici ezingavamile ze-coagulation endleleni engapheli, njenge-factor 12, factor 9, factor 8, kanye nendlela evamile 10. Ukuntuleka kwesici kungabangela izimpawu zokopha ezigulini;

2. Indlela engavamile ye-coagulation yangaphandle: uma i-PT ithatha isikhathi eside, ingatholakala ukuthi isici se-tissue, i-factor 5 kanye ne-factor 10 endleleni evamile kungase kube okungavamile, okungukuthi, ukwehla kwenombolo kuholela esikhathini eside sokuhlangana futhi kubangele ukopha. esigulini.