Izinkomba zokuhlola ukusebenza kwe-coagulation zifaka isikhathi se-prothrombin (PT), isikhathi se-thrombin thromboplastin esicushiwe (APTT), isikhathi se-thrombin (TT), i-fibrinogen (FIB), isikhathi sokuvala (CT) kanye nesilinganiso esijwayelekile samazwe ngamazwe (INR), njll., izinto ezimbalwa zingaba ekhethiwe ukwenza iphakheji, ebizwa ngokuthi into ye-coagulation X.Ngenxa yezindlela zokuhlonza ezihlukene ezisetshenziswa izibhedlela ezahlukene, izigaba zereferensi nazo zihlukile.

Isikhathi se-PT-prothrombin

I-PT ibhekisela ekwengezeni i-tissue factor (TF noma i-tishu thromboplastin) kanye ne-Ca2+ ku-plasma ukuze kuqalwe uhlelo lwe-extrinsic coagulation kanye nokubheka isikhathi sokuhlangana kwe-plasma.I-PT ingenye yokuhlolwa kokuhlola okuvame ukusetshenziswa kakhulu ekusebenzeni komtholampilo ukuze kuhlolwe umsebenzi we-extrinsic coagulation pathway.Inani elijwayelekile lereferensi liyimizuzwana eyi-10 kuye kweyi-14.

I-APTT - isikhathi se-thromboplastin esicushiwe

I-APTT iwukwengeza i-XII factor activator, i-Ca2+, i-phospholipid ku-plasma ukuze kuqalwe indlela ye-plasma endogenous coagulation, nokubheka isikhathi sokuhlangana kwe-plasma.I-APTT iphinde ibe ngolunye lwezivivinyo zokuhlola ezivame ukusetshenziswa kakhulu ekusebenzeni komtholampilo ukuze kuhlolwe umsebenzi wendlela ye-intrinsic coagulation.Inani elijwayelekile lereferensi lingamasekhondi angu-32 kuya kwangu-43.

INR - Isilinganiso Esijwayelekile Samazwe Ngamazwe

I-INR amandla e-ISI esilinganiso se-PT yesiguli esihloliwe kuya ku-PT yokulawula okujwayelekile (i-ISI inkomba yokuzwela yamazwe ngamazwe, futhi i-reagent ilinganiswa ngumkhiqizi lapho iphuma efektri).I-plasma efanayo ihlolwe ngama-reagents e-ISI ahlukene ezindaweni zokucwaninga ezihlukene, futhi imiphumela yenani le-PT yayihluke kakhulu, kodwa amanani e-INR alinganisiwe ayefana, okwenza imiphumela yaqhathaniswa.Inani elijwayelekile lereferensi ngu-0.9 kuye ku-1.1.

Isikhathi se-TT-thrombin

I-TT iwukwengezwa kwe-thrombin evamile ku-plasma ukuze kutholwe isigaba sesithathu senqubo yokuhlangana, okubonisa izinga le-fibrinogen ku-plasma kanye nenani lezinto ezinjenge-heparin ku-plasma.Inani elijwayelekile lereferensi liyimizuzwana engu-16 ukuya kwangu-18.

I-FIB-fibrinogen

I-FIB iwukwengeza inani elithile le-thrombin ku-plasma ehloliwe ukuze iguqule i-fibrinogen ku-plasma ibe yi-fibrin, futhi ubale okuqukethwe kwe-fibrinogen ngomgomo we-turbidimetric.Inani elijwayelekile lereferensi ngu-2 kuya ku-4 g/L.

Umkhiqizo wokuwohloka kwe-FDP-plasma fibrin

I-FDP igama elivamile lemikhiqizo ewohlokayo ekhiqizwa ngemva kokubola kwe-fibrin noma i-fibrinogen ngaphansi kwesenzo se-plasmin ekhiqizwa ngesikhathi se-hyperfibrinolysis.Inani elijwayelekile lereferensi ngu-1 kuya ku-5 mg/L.

Isikhathi se-CT-coagulation

I-CT ibhekisela esikhathini lapho igazi liphuma emithanjeni yegazi futhi lihlangane ku-vitro.Inquma ngokuyinhloko ukuthi ingabe izici ezihlukahlukene zokuhlangana kumzila we-intrinsic coagulation ziyashoda, noma ngabe umsebenzi wazo ujwayelekile, noma ingabe kukhona ukwanda kwezinto ezilwa nokuvuvukala.