I-Thrombosis ngokuvamile inezimo ezintathu ezilandelayo:

1. Inhliziyo nemithambo yegazi ukulimala intima

I-intima yenhliziyo evamile nemithambo yegazi iqinile futhi ibushelelezi, futhi amangqamuzana e-endothelial angaqinile angavimbela ukunamathela kweplatelet kanye ne-anticoagulation.Lapho ulwelwesi lwangaphakathi lonakalisiwe, uhlelo lwe-coagulation lungenziwa lusebenze ngezindlela eziningi.

I-intima yokuqala eyonakele ikhipha i-tissue coagulation factor (i-coagulation factor III), eyenza kusebenze uhlelo lwe-extrinsic coagulation.
Okwesibili, ngemva kokulimala kwe-intima, amangqamuzana e-endothelial ayancipha, i-necrosis, nokuchithwa, eveza imicu ye-collagen ngaphansi kwe-endothelium, ngaleyo ndlela asebenze i-coagulation factor XII ye-endogenous coagulation system futhi aqale uhlelo lwe-endogenous coagulation.Ngaphezu kwalokho, i-intima eyonakele iba lukhuni, evumela ukubekwa kweplatelet nokunamathela.Ngemuva kokuqhekeka kwamaplatelet abambelele, kudedelwa izici ezahlukahlukene zeplatelet, futhi yonke inqubo yokuhlangana icushwe, okwenza igazi lihlangane futhi lenze i-thrombus.
Izici ezihlukahlukene ezingokomzimba, zamakhemikhali nezezinto eziphilayo zingabangela ukulimala kwe-intima yenhliziyo, njenge-endocarditis ku-erysipelas yezingulube, i-pulmonary vasculitis e-bovine pneumonia, i-equine parasitic arteritis, ukujova okuphindaphindiwe engxenyeni efanayo yomthambo, Ukulimala nokubhoboza odongeni lomkhumbi wegazi. ngesikhathi sokuhlinzwa.

2. Izinguquko esimweni sokugeleza kwegazi

Ikakhulukazi ibhekise ekugelezeni kwegazi okunensayo, ukwakheka kwe-vortex kanye nokunqamuka kokugeleza kwegazi.
Ngaphansi kwezimo ezijwayelekile, izinga lokugeleza kwegazi liyashesha, futhi amangqamuzana egazi abomvu, ama-platelet nezinye izingxenye zigxilwe phakathi nendawo yomkhumbi wegazi, okubizwa ngokuthi ukugeleza kwe-axial;lapho izinga lokugeleza kwegazi lehla, amangqamuzana egazi abomvu namaplatelet azogeleza eduze kodonga lwemithambo yegazi, olubizwa ngokuthi ukugeleza kwezinhlangothi, okwandisa i-thrombosis.ingozi evelayo.
Ukugeleza kwegazi kuyehla, futhi amangqamuzana e-endothelial ane-hypoxic kakhulu, okubangela ukuwohloka kanye ne-necrosis yamangqamuzana e-endothelial, ukulahlekelwa umsebenzi wawo wokuhlanganiswa nokukhulula izici ze-anticoagulant, kanye nokuvezwa kwe-collagen, eyenza uhlelo lwe-coagulation lusebenze futhi lukhuthaze. i-thrombosis.
Ukugeleza kwegazi okunensayo nakho kungenza i-thrombus eyakhiwe kube lula ukulungisa odongeni lwemithambo yegazi futhi iqhubeke nokwanda.

Ngakho-ke, i-thrombus ivame ukwenzeka emithanjeni enegazi elihamba kancane futhi ejwayele ukuba nama-eddy currents (kuma-valve e-venous).Ukugeleza kwegazi kwe-aortic kuyashesha, futhi i-thrombus ayivamisile ukubonakala.Ngokwezibalo, ukuvela kwe-venous thrombosis kuphindwe izikhathi ezi-4 kune-arterial thrombosis, futhi i-venous thrombosis ivame ukwenzeka ekuhlulekeni kwenhliziyo, ngemva kokuhlinzwa noma ezilwaneni ezigulayo ezilele esidlekeni isikhathi eside.
Ngakho-ke, kubaluleke kakhulu ukusiza izilwane ezigulayo ezilele phansi isikhathi eside futhi ngemva kokuhlinzwa ukwenza imisebenzi ethile efanele ukuvimbela i-thrombosis.
3. Izinguquko ezicini zegazi.

Ikakhulukazi ibhekisela ekwandeni kwe-coagulation yegazi.Njengokushisa okukhulu, ukuphelelwa amandla kwamanzi, njll. ukugxilisa igazi, ukuhlukumezeka okukhulu, ukubeletha, nokulahlekelwa okukhulu kwegazi ngemva kokuhlinzwa okukhulu kungandisa inani lama-platelet egazini, kwandise i-viscosity yegazi, futhi kwandise okuqukethwe kwe-fibrinogen, i-thrombin nezinye izici ze-coagulation. ku-plasma Ukwanda.Lezi zici zingabangela i-thrombosis.