Isibindi siyindawo yokuhlanganisa izici ezihlukahlukene zokuhlangana, futhi singahlanganisa futhi singasebenzi ama-fibrin lysates nezinto ze-antifibrinolytic, futhi sidlale indima yokulawula ekugcineni ibhalansi eguquguqukayo ye-coagulation kanye nohlelo lwe-anticoagulation.Ukutholwa kwezinkomba ze-blood coagulation ezigulini ezine-hepatitis B kubonise ukuthi kwakungekho umehluko omkhulu ku-PTAPTT ezigulini ezine-hepatitis B engapheli uma kuqhathaniswa neqembu elivamile lokulawula (P> 0.05), kodwa kwakukhona umehluko omkhulu ku-FIB (P<0.05 ).Kube nomehluko omkhulu ku-PT, APTT, kanye ne-FIB phakathi kweqembu elinzima le-hepatitis B kanye neqembu elivamile lokulawula (P<005P<0.01), elifakazele ukuthi ukuqina kwesifo sokusha kwesibindi kohlobo B kwakuhlobene kahle nokuncipha kwamazinga esici se-blood coagulation.

Ukuhlaziywa kwezizathu zemiphumela engenhla:

1. Ngaphandle kwe-factor IV (Ca *) ne-cytoplasm, ezinye izici ze-plasma coagulation zenziwa esibindi;izici ze-anticoagulation (i-coagulation inhibitors) njenge-ATIPC, i-2-MaI-AT, njll. nazo zihlanganiswa yisibindi.ukuhlanganiswa kwamaselula.Lapho amangqamuzana esibindi alimele noma ama-necrotic ngamazinga ahlukene, ikhono lesibindi lokuhlanganisa izici ze-coagulation kanye nezici eziphikisana ne-coagulation liyancishiswa, futhi amazinga e-plasma alezi zici nawo ayancishiswa, okubangela izithiyo endleleni yokuhlangana.I-PT iwukuhlolwa kokuhlolwa kwe-extrinsic coagulation system, engabonisa izinga, umsebenzi kanye nomsebenzi we-coagulation factor IV VX ku-plasma.Ukwehliswa kwalezi zici ezingenhla noma izinguquko emisebenzini nasemisebenzini yazo kube esinye sezizathu ze-PT isikhathi eside ezigulini ezine-post-hepatitis B cirrhosis kanye ne-hepatitis B enzima. Ngakho-ke, i-PT ivame ukusetshenziswa emtholampilo ukuze ibonise ukuhlanganiswa kwe-coagulation. izici esibindini.

2. Ngakolunye uhlangothi, ngokulimala kwamangqamuzana esibindi nokuhluleka kwesibindi ezigulini ze-hepatitis B, izinga le-plasmin ku-plasma liyakhula ngalesi sikhathi.I-Plasmin ayikwazi kuphela ukugcwalisa inani elikhulu le-fibrin, i-fibrinogen kanye nezici eziningi zokuhlangana ezifana nokuqeqeshwa kwesici, i-XXX, i-VVII,Ⅱ, njll., kodwa futhi kudla inani elikhulu lezici ezilwa nokuhlangana njenge-ATⅢPC nokunye.Ngakho-ke, ngokujula kwalesi sifo, i-APTT yanda futhi i-FIB yehla kakhulu ezigulini ze-hepatitis B.

Sengiphetha, ukutholwa kwezinkomba ze-coagulation ezifana ne-PTAPTTFIB kunokubaluleka komtholampilo okubaluleke kakhulu ekwahluleleni isimo seziguli ezine-hepatitis B engapheli, futhi kuyinkomba yokutholwa ebucayi nethembekile.