Kungenzeka ukwazi ukuthi isiguli sinomsebenzi we-coagulation ongavamile ngaphambi kokuhlinzwa, ukuvimbela ngempumelelo izimo ezingalindelekile ezifana nokopha okunganqamuki phakathi nangemuva kokuhlinzwa, ukuze kutholwe umphumela wokuhlinzwa ongcono kakhulu.
Umsebenzi we-hemostatic womzimba ufezwa isenzo esihlangene samaplatelet, uhlelo lokuhlangana, uhlelo lwe-fibrinolytic kanye ne-vascular endothelial system.Esikhathini esedlule, sasisebenzisa isikhathi sokopha njengokuhlola ukukhubazeka komsebenzi we-hemostatic, kodwa ngenxa yokumiswa kwayo okuphansi, ukuzwela okubuthakathaka, kanye nokungakwazi ukukhombisa okuqukethwe nomsebenzi wezici zokuhlangana, kuthathelwe indawo ukuhlolwa kokusebenza kwe-coagulation.Ukuhlolwa kokusebenza kwe-coagulation ikakhulukazi kufaka phakathi isikhathi se-plasma prothrombin (PT) nomsebenzi we-PT obalwe kusukela ku-PT, isilinganiso samazwe ngamazwe esijwayelekile (INR), i-fibrinogen (FIB), isikhathi se-thromboplastin esiyingxenye esicushiwe (APTT) nesikhathi se-plasma thrombin (TT).
I-PT ikhombisa ngokuyinhloko umsebenzi we-extrinsic coagulation system.I-PT ende ibonakala ngokuyinhloko ekuncishisweni kwe-congenital coagulation factor II, V, VII, kanye ne-X, ukushoda kwe-fibrinogen, ukuntula okutholakele kwe-coagulation factor (DIC, i-hyperfibrinolysis eyinhloko, i-jaundice evimbelayo, ukuntula kwe-vitamin K, kanye nezinto ezilwa ne-anticoagulant ekuhambeni kwegazi. ikakhulukazi kubonakala ekukhuleni kokuzalwa kwe-coagulation factor V, i-DIC yokuqala, izifo ze-thrombotic, izinto zokuvimbela inzalo ngomlomo, njll.; Ukuqapha i-PT kungasetshenziswa njengokuqapha izidakamizwa zomlomo zomtholampilo.
I-APTT ukuhlolwa kokuhlola okuthembeke kakhulu kokushoda kwe-endogenous coagulation factor.I-APTT ende ibonakala ngokuyinhloko ku-hemophilia, i-DIC, isifo sesibindi, nokumpontshelwa okukhulu kwegazi lasebhange.I-APTT efinyeziwe ibonakala kakhulu ku-DIC, isimo se-prothrombotic, kanye nezifo ze-thrombotic.I-APTT ingasetshenziswa njengenkomba yokuqapha yokwelashwa kwe-heparin.
Ukwelulwa kwe-TT kubonakala ku-hypofibrinogenemia ne-dysfibrinogenemia, ukwanda kwe-FDP egazini (DIC), nokuba khona kwe-heparin ne-heparinoid izinto egazini (isb, ngesikhathi sokwelashwa kwe-heparin, i-SLE, isifo sesibindi, njll.).
Kwake kwaba nesiguli esiphuthumayo esathola izivivinyo zaselabhorethri zangaphambi kokuhlinzwa, futhi imiphumela yokuhlolwa kwe-coagulation yanwetshwa i-PT ne-APTT, kanti i-DIC yasolwa esigulini.Ngaphansi kwesincomo selabhorethri, isiguli senza uchungechunge lokuhlolwa kwe-DIC futhi imiphumela yaba nethemba.Azikho izimpawu ezisobala ze-DIC.Uma isiguli singenakho ukuhlolwa kwe-coagulation, nokuhlinzwa okuqondile, imiphumela iyoba yinhlekelele.Izinkinga eziningi ezinjalo zingatholakala ekuhlolweni kokusebenza kwe-coagulation, okuthenge isikhathi esengeziwe sokutholwa nokwelashwa kwezifo emtholampilo.Ukuhlolwa kochungechunge lwe-coagulation kuwukuhlola kwaselabhorethri okubalulekile kokusebenza kwe-coagulation yeziguli, okungathola ukusebenza okungavamile kokuhlangana ezigulini ngaphambi kokuhlinzwa, futhi kufanele kunakwe ngokwanele.
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