Umzimba ojwayelekile unohlelo oluphelele lwe-coagulation kanye ne-anticoagulation.I-coagulation system kanye ne-anticoagulation system igcina ibhalansi eguquguqukayo ukuze kuqinisekiswe ukopha komzimba nokugeleza kwegazi okushelelayo.Uma ibhalansi ye-coagulation kanye ne-anticoagulation iphazamisekile, kuzoholela ekopheni kanye nokuthambekela kwe-thrombosis.

1. Umsebenzi wokuhlangana komzimba

Uhlelo lwe-coagulation ikakhulukazi lwakhiwe izici zokuhlangana.Izinto ezibandakanyeka ngokuqondile ekuhlanganiseni zibizwa ngokuthi ama-coagulation factor.Kunezici eziqashelwayo ze-coagulation eziyi-13.

Kunezindlela zokuvula ze-endogenous kanye nezindlela zokuvula zangaphandle zokuvula izici ze-coagulation.

Njengamanje kukholakala ukuthi ukusebenza kwe-exogenous coagulation system eqalwa yi-tissue factor idlala indima enkulu ekuqaliseni ukuhlangana.Ukuxhumana okuseduze phakathi kwezinhlelo ze-coagulation zangaphakathi nezangaphandle kudlala indima ebalulekile ekuqaliseni nasekugcineni inqubo yokuhlanganisa.

2. Umsebenzi we-anticoagulant womzimba

Uhlelo lwe-Anticoagulation luhlanganisa uhlelo lwe-anticoagulation lwamaselula kanye nesistimu ye-anticoagulation yomzimba.

①Isistimu ye-cell anticoagulation

Ibhekisela ku-phagocytosis ye-coagulation factor, i-tissue factor, i-prothrombin complex kanye ne-soluble fibrin monomer ngohlelo lwe-mononuclear-phagocyte.

②Isistimu ye-anticoagulation yoketshezi lomzimba

Kubandakanya: ama-serine protease inhibitors, ama-protein C-based protease inhibitors kanye nama-tissue factor pathway inhibitors (TFPI).

3. Uhlelo lweFibrinolytic nemisebenzi yalo

Ikakhulukazi i-plasminogen, i-plasmin, i-activator ye-plasminogen kanye ne-fibrinolysis inhibitor.

Indima yesistimu ye-fibrinolytic: chaza amahlule e-fibrin futhi uqinisekise ukujikeleza kwegazi okushelelayo;iqhaza ekulungiseni izicubu kanye nokuvuselelwa kwemithambo.

4. Indima yamaseli e-vascular endothelial enqubweni ye-coagulation, i-anticoagulation kanye ne-fibrinolysis.

① Khiqiza izinto ezahlukahlukene eziphilayo ezisebenzayo;

②Lawula ukujiya kwegazi nokusebenza kwe-anticoagulation;

③Lungisa umsebenzi wesistimu ye-fibrinolysis;

④ Lawula ukungezwani kwemithambo;

⑤Bamba iqhaza ekulamuleni ukuvuvukala;

⑥Gcina umsebenzi we-microcirculation, njll.

Ukuphazamiseka kwe-coagulation kanye ne-anticoagulant

1. Ukungajwayelekile ezicini zokuhlangana.

2. Ukungajwayelekile kwezici ze-anticoagulant ku-plasma.

3. Ukungajwayelekile kwe-fibrinolytic factor ku-plasma.

4. Ukungajwayelekile kwamangqamuzana egazi.

5. Imithambo yegazi engavamile.