Isikhathi se-Prothrombin (PT) siyinkomba ebaluleke kakhulu yokubonisa umsebenzi wokuhlanganiswa kwesibindi, umsebenzi wokugodla, ubunzima besifo kanye nokubikezelwa.Njengamanje, ukutholwa komtholampilo kwezici ze-coagulation kuye kwaba ngokoqobo, futhi kuzohlinzeka ngolwazi lwangaphambili futhi olunembile kune-PT ekwahluleleni isimo sesifo sesibindi.

Ukusetshenziswa komtholampilo kwe-PT kusifo sesibindi:

Ilabhorethri ibika i-PT ngezindlela ezine: i-prothrombintime activitypercentagePTA (prothrombin time ratio PTR) kanye ne-INR yesilinganiso esijwayelekile samazwe ngamazwe.Amafomu amane anezilinganiso ezihlukene zesicelo somtholampilo.

Inani lesicelo se-PT esifweni sesibindi: I-PT inqunywa ngokuyinhloko izinga le-coagulation factor IIvX ehlanganiswe isibindi, futhi indima yayo ekuguleni kwesibindi ibaluleke kakhulu.Izinga elingavamile le-PT ku-hepatitis eyingozi lalingu-10% -15%, i-hepatitis engapheli yayingu-15% -51%, i-cirrhosis yayingu-71%, kanti i-hepatitis enzima yayingu-90%.Ezimweni zokuxilonga i-viral hepatitis ngo-2000, i-PTA ingenye yezinkomba zesigaba somtholampilo seziguli ezine-viral hepatitis.Iziguli ezine-viral hepatitis ezingapheli ezine-PTA emnene>70%, ezimaphakathi 70% -60%, ezinzima 60% -40%;i-cirrhosis enesiteji esinxeshezelwe i-PTA>60% isigaba se-PTA esincishisiwe <60%;I-hepatitis enzima ye-PTA <40%" Esigabeni se-Child-Pugh, iphoyinti elingu-1 lokwelulwa kwe-PT kwe-1 ~ 4s, amaphuzu ama-2 we-4 ~ 6s, amaphuzu angu-3 we->6s, kuhlanganiswe nezinye izinkomba ezi-4 (i-albumin, i-bilirubin, i-ascites, i-encephalopathy ), ukusebenza kwesibindi kweziguli ezinesifo sesibindi Izinqolobane zihlukaniswe ngamamaki e-ABC; isikolo se-MELD (i-Modelfor end-stageliver disease), esinquma ukuqina kwesifo ezigulini ezinesifo sesibindi sokuphela kanye nokulandelana kokufakelwa kwesibindi, ifomula ithi .8xloge[bilirubin(mg/dl)+11.2xloge(INR)+ 9.6xloge[creatinine (mg/dl]+6.4x (isizathu: i-biliary noma i-alcohol 0; enye 1), i-INR ingenye yezinkomba ezi-3.

I-Diagnostic criteria ye-DIC yesifo sesibindi ihlanganisa: Ukwelulwa kwe-PT okungaphezu kwe-5s noma isikhathi esisebenzayo se-thromboplastin esiyingxenye (APTT) ngaphezu kwe-10s, umsebenzi we-factor VIII <50% (iyadingeka);I-PT kanye ne-platelet count kuvame ukusetshenziselwa ukuhlola i-biopsy yesibindi kanye nokuhlinzwa Ukuthambekela ukopha kweziguli, njengamaplatelet <50x10°/L, kanye nokwelulwa kwe-PT okudlula okujwayelekile kwama-4s kuwukungqubuzana kwe-biopsy yesibindi nokuhlinzwa okuhlanganisa ukufakelwa kwesibindi.Kungabonakala ukuthi i-PT idlala indima ebalulekile ekuxilongeni nasekwelapheni iziguli ezinesifo sesibindi.