Ikhithi Yesikhathi Ye-Thromboplastin Esebenzayo (APTT)

Ukulinganisa kwe-APTT ukuhlola okuvamise ukusetshenziswa okubucayi komtholampilo ukuze kubonise umsebenzi wokuhlanganisa wesistimu ye-endogenous coagulation.Isetshenziselwa ukuthola ukukhubazeka kwe-endogenous coagulation factor kanye nama-inhibitors ahlobene kanye nokuhlola isenzakalo sokusebenza kwe-protein C ukumelana.Inezinhlobonhlobo zezicelo mayelana nokuhlolwa, ukuqapha ukwelashwa kwe-heparin, ukuxilongwa kusenesikhathi kwe-dissemination intravascular coagulation (DIC), kanye nokuhlolwa kwangaphambi kokuhlinzwa.

Ukubaluleka komtholampilo:

I-APTT inkomba yokuhlola ukusebenza kwe-coagulation ebonisa indlela ye-endogenous coagulation, ikakhulukazi umsebenzi obanzi wezici zokuhlangana esigabeni sokuqala.Isetshenziswa kabanzi ukuze kuhlolwe futhi kunqunywe ukukhubazeka kwezinto ezithinta i-coagulation ku-endogenous pathway, njenge-factor Ⅺ , Ⅷ, Ⅸ, ingase futhi isetshenziselwe ukuhlolwa kokuqala kwezifo ezophayo kanye nokuqapha ilabhorethri ye-heparin anticoagulation therapy.

1. Isikhathi eside: singabonakala ku-hemophilia A, i-hemophilia B, isifo sesibindi, isifo sokuvala inzalo emathunjini, ama-anticoagulants omlomo, i-diffuse intravascular coagulation, i-hemophilia emnene;FXI, FXII ukuntula;igazi Anticoagulant izinto (coagulation factor inhibitors, lupus anticoagulants, warfarin noma heparin) anda;igazi eliningi eligciniwe lampontshelwa.

2. Fushanisa: Kungabonakala esimweni se-hypercoagulable, izifo ze-thromboembolic, njll.

Ububanzi bereferensi bevelu evamile

Inani elijwayelekile lereferensi lesikhathi se-thromboplastin esiyingxenye esicushiwe (APTT): amasekhondi angu-27-45.

Izinyathelo zokuzivikela

1. Gwema isampula ye-hemolysis.Isampula ye-hemolyzed iqukethe ama-phospholipids akhishwe ngokugqashuka kolwelwesi oluvuthiwe lwengqamuzana legazi elibomvu, okwenza i-APTT ibe phansi kunevelu elinganiselwe yesampula engafakwanga i-hemolyzed.

2. Iziguli akufanele zihlanganyele emisebenzini enzima phakathi nemizuzu engama-30 ngaphambi kokuthatha amasampula egazi.

3. Ngemva kokuqoqa isampula yegazi, nyakazisa ishubhu lokuhlola elinesampula legazi izikhathi ezi-3 kuya kwezi-5 ukuze uhlanganise ngokugcwele isampula yegazi ne-anticoagulant eshubhu lokuhlola.

4. Amasampula egazi kufanele athunyelwe ukuze ahlolwe ngokushesha ngangokunokwenzeka.