Ara deede ni eto coagulation pipe ati eto anticoagulation.Eto coagulation ati eto anticoagulation ṣetọju iwọntunwọnsi agbara lati rii daju hemostasis ti ara ati sisan ẹjẹ didan.Ni kete ti iṣọn-ẹjẹ ati iwọntunwọnsi iṣẹ anticoagulation jẹ idamu, yoo ja si ẹjẹ ati itara thrombosis.

1. Awọn ara ile coagulation iṣẹ

Eto coagulation jẹ nipataki ti awọn ifosiwewe coagulation.Awọn nkan ti o ni ipa taara ninu iṣọn-ẹjẹ ni a pe ni awọn ifosiwewe coagulation.Awọn ifosiwewe coagulation 13 ti a mọ.

Awọn ipa-ọna imuṣiṣẹ endogenous wa ati awọn ipa ọna imuṣiṣẹ exogenous fun imuṣiṣẹ ti awọn ifosiwewe coagulation.

Lọwọlọwọ o gbagbọ pe ṣiṣiṣẹ ti eto coagulation exogenous ti ipilẹṣẹ nipasẹ ifosiwewe tissu ṣe ipa pataki ninu ibẹrẹ ti coagulation.Isopọ ti o sunmọ laarin awọn eto inu inu ati ita ti ita n ṣe ipa pataki ni ibẹrẹ ati mimu ilana ilana coagulation.

2. Iṣẹ anticoagulant ti ara

Eto anticoagulation pẹlu eto anticoagulation cellular ati eto anticoagulation ti omi ara.

① Eto ajẹsara sẹẹli

Ntọka si phagocytosis ti coagulation ifosiwewe, àsopọ ifosiwewe, prothrombin eka ati tiotuka fibrin monomer nipasẹ awọn mononuclear-phagocyte eto.

② Ètò ìsokọ́ra omi ara

Pẹlu: awọn inhibitors protease serine, amuaradagba C-orisun protease inhibitors ati awọn inhibitors ipa ọna ti ara (TFPI).

3. Fibrinolytic eto ati awọn oniwe-iṣẹ

Ni akọkọ pẹlu plasminogen, plasmin, plasminogen activator ati inhibitor fibrinolysis.

Ipa ti eto fibrinolytic: tu awọn didi fibrin ati rii daju sisan ẹjẹ didan;kopa ninu atunṣe àsopọ ati isọdọtun iṣan.

4. Ipa ti awọn sẹẹli endothelial ti iṣan ni ilana ti coagulation, anticoagulation ati fibrinolysis

① Ṣe agbejade ọpọlọpọ awọn nkan ti nṣiṣe lọwọ biologically;

② Ṣe atunṣe iṣọn-ẹjẹ ẹjẹ ati iṣẹ anticoagulation;

③ Ṣatunṣe iṣẹ ti eto fibrinolysis;

④ Ṣe atunṣe ẹdọfu ti iṣan;

⑤ Kopa ninu ilaja ti iredodo;

⑥ Ṣe itọju iṣẹ ti microcirculation, ati bẹbẹ lọ.

Coagulation ati awọn rudurudu anticoagulant

1. Aiṣedeede ninu awọn ifosiwewe coagulation.

2. Aiṣedeede ti awọn ifosiwewe anticoagulant ni pilasima.

3. Aiṣedeede ti fibrinolytic ifosiwewe ni pilasima.

4. Aiṣedeede ti awọn sẹẹli ẹjẹ.

5. Awọn ohun elo ẹjẹ ajeji.