I-Thrombin luhlobo lwento emhlophe ukuya kungwevu-emhlophe engeyiyo ikristale, ngokubanzi ingumkhenkce -umgubo owomileyo.ITHROMBIN luhlobo oluthile lwento emhlophe ukuya kungwevu-mhlophe engeyiyo ikristale, ngokubanzi ingumkhenkce -umgubo owomileyo.

I-Thrombin ikwabizwa ngokuba yi-coagulation factor Ⅱ, eyona nto i-multifunctional coagulation factor.Umsebenzi ophambili kukubola i-fibrin yoqobo, yenza i-fibrin primary tetrachide nganye ikhuphe amacandelo amane eepeptides ezincinci, kwaye inxalenye eseleyo yi-fiber protein monomer.Ezi monomers ziyadityaniswa ukwenza umnatha okhululekileyo, onyibilikayo.Ngaphantsi kwesenzo se-coagulation factor ions kunye ne-calcium ions, i-fibrin monomers idibanisa enye kwenye ukuze yenze i-clot ye-fibrin polymer enganyibilikiyo.

I-Thrombin yeyona nto ibaluleke kakhulu kwi-coagulation kwinkqubo yokudibanisa komntu.Umsebenzi oyintloko kukuvula i-fibrinogen yomzimba womntu kwaye wenze i-fibrin yokuqala ibe yi-fibrin esebenzayo, enokuthi idlale indima yokudibanisa ngokukhawuleza.Kwangaxeshanye, i-coagulinase inokuthi iphinde ibe nengxelo engalunganga yokukhawulezisa i-intrinsic coagulation pathway kunye ne-coagulation ye-exogenous coagulation pathway, edlala indima ebalulekileyo kwinkqubo yokudibanisa umzimba womntu.Ukongeza, i-coordinase ikwaligama elisetyenziswa ngokuqhelekileyo lamachiza e-hemostatic asetyenziswa ngokuqhelekileyo kwiikliniki.Ifaneleka ikakhulu kwizifo ezinjengokopha kwenkqubo yokwetyisa, ukopha ngotyando, ukopha kwezifo zabafazi.Inezibonakaliso ezingqongqo kwaye kufuneka isetyenziswe phantsi kolawulo loogqirha.