I-PT ithetha ixesha le-prothrombin kwiyeza, kwaye i-APTT ithetha ukuba i-thromboplastin isebenze ixesha elithile kwiyeza.Umsebenzi wokudibanisa igazi womzimba womntu ubaluleke kakhulu.Ukuba umsebenzi wokudibanisa igazi awuqhelekanga, unokukhokelela kwi-thrombosis okanye ukopha, nto leyo enokubeka engozini ngokunzulu ubomi besigulane.Ukuhlolwa kweklinikhi ye-PT kunye ne-APTT yamaxabiso ingasetyenziswa njengomgangatho wokusetyenziswa kwamanye amachiza e-anticoagulant kwimisebenzi yeklinikhi.Ukuba ixabiso elilinganisiweyo liphezulu kakhulu, kuthetha ukuba umthamo wamachiza e-anticoagulant kufuneka uncitshiswe, ngaphandle koko ukuphuma kwegazi kuya kwenzeka lula.

1. Ixesha leProthrombin (PT): Sesinye sezibonakaliso ezibukhali zenkqubo ye-blood coagulation system.Kunentsingiselo ngakumbi ukolula ixesha elingaphezulu kwemizuzwana emi-3 kuqheliselo lwezonyango, olunokubonisa ukuba umsebenzi we-coagulation wangaphandle uqhelekile.Ukwandiswa ngokuqhelekileyo kubonakala kwi-congenital coagulation Ukusilela kweFactor, i-cirrhosis enzima, ukungaphumeleli kwesibindi kunye nezinye izifo.Ukongezelela, iidosi ezigqithisileyo ze-heparin kunye ne-warfarin nazo zingabangela i-PT ende;

2. Ixesha elisebenzayo le-thromboplastin (APTT): Ikakhulu isalathiso esibonisa umsebenzi we-endogenous blood coagulation ekusebenzeni kweklinikhi.Ukolulwa okubalulekileyo kwe-APTT kubonwa ikakhulu kukusilela kokuzalwa okanye okufunyenweyo kwe-coagulation factor, efana ne-hemophilia kunye ne-systemic lupus erythematosus.Ukuba idosi yamachiza e-anticoagulant esetyenziswa ngenxa ye-thrombosis ayiqhelekanga, iya kubangela ukwanda okubonakalayo kwe-APTT.Ukuba ixabiso elilinganisiweyo liphantsi, cinga ukuba isigulane sikwimeko ye-hypercoagulable, njenge-deep vein thrombosis.

Ukuba ufuna ukwazi ukuba ngaba i-PT kunye ne-APTT ziqhelekile na, kufuneka ucacise uluhlu lwazo oluqhelekileyo.Uluhlu oluqhelekileyo lwe-PT luyi-11-14 imizuzwana, kwaye uluhlu oluqhelekileyo lwe-APTT luyi-27-45 imizuzwana.Ukwandiswa kwe-PT ngaphezu kwemizuzwana ye-3 kunokubaluleka okukhulu kweklinikhi, kwaye i-APTT yokwandisa ngaphezu kwemizuzwana ye-10 inokubaluleka okunamandla kwekliniki.