I-Thrombosis ngokuqhelekileyo ibangelwa ngumonakalo kwiiseli ze-cardiovascular endothelial, isimo esingaqhelekanga sokuhamba kwegazi, kunye nokunyuka kwegazi.

1. Ukulimala kweeseli ze-cardiovascular endothelial cell: Ukulimala kwe-Vascular endothelial cell iyona nto ibalulekileyo kunye neyona nto ibangela ukubunjwa kwe-thrombus, eyona nto ixhaphake kakhulu kwi-rheumatic and infective endocarditis, i-atherosclerotic plaque ulcer enzima, i-traumatic or inflammatory motion site ye-venous ukulimala, njl. emva kwe-hypoxia, ukothuka, i-sepsis kunye ne-endotoxin yebhaktiriya kubangela umonakalo omkhulu we-endothelial kuwo wonke umzimba, i-collagen phantsi kwe-endothelium isebenze inkqubo yokudibanisa, okukhokelela ekuhanjisweni kwe-intravascular coagulation, kunye neefom ze-thrombus kwi-microcirculation yomzimba wonke.

2. Imeko engaqhelekanga yokuhamba kwegazi: ikakhulu ibhekisa ekucothiseni ukuhamba kwegazi kunye nokuveliswa kweeeddies ekuhambeni kwegazi, njl. ukubunjwa kwe-thrombus.Phakathi kwabo, i-veins iyancipha ngakumbi kwi-thrombus, exhaphake kakhulu kwizigulane ezinentliziyo, izifo ezingapheliyo kunye nokuphumla kwebhedi emva kokusebenza.Ukongezelela, ukuhamba kwegazi entliziyweni kunye nemithambo yegazi ngokukhawuleza, kwaye akulula ukwenza i-thrombus.Nangona kunjalo, xa igazi lihamba kwi-atrium yasekhohlo, i-aneurysm, okanye isebe lomthambo wegazi licotha kwaye i-eddy yangoku iyenzeka ngexesha le-mitral valve stenosis, iphinda ihlasele i-thrombosis.

3. Ukunyuka kwe-blood coagulation: Ngokuqhelekileyo, ukwanda kweeplatelet kunye ne-coagulation factor in the blood, okanye ukuncipha komsebenzi we-fibrinolytic system, kukhokelela kwi-hypercoagulable state kwigazi, eliqhelekileyo kwi-hereditary kunye ne-hypercoagulable state.

Ukongeza, ukubuya kakubi kwegazi le-venous nako kunokubangela oko.Ngokokuxilongwa okusebenzayo kwesifo somntu, uthintelo lwenzululwazi olujoliswe kuyo kunye nonyango lunokufezekiswa ukunceda ukubuyiswa kwempilo.