I-APTT sisishunqulelo sesiNgesi sexesha leprothrombin elisekwe ngokuyinxenye.I-APTT luvavanyo lokuhlola olubonisa indlela ye-endogenous coagulation.I-APTT yexesha elide ibonisa ukuba i-blood coagulation factor ethile ebandakanyeka kwindlela ye-endogenous coagulation pathway ayisebenzi.Emva kokuba i-APTT ithathe ixesha elide, isigulane siya kuba neempawu ezicacileyo zokopha.Ngokomzekelo, abaguli abane-hemophilia A, i-hemophilia B, kunye nesifo sika-von Willebrand bonke baya kuba ne-APTT ende, kwaye umguli uya kuba ne-ecchymosis eluswini kunye ne-mucous membrane, kunye nokopha kwemisipha., ukopha ngokudibeneyo, i-hematoma, njl. Ngokukodwa kwizigulane ezine-hemophilia A, ukukhubazeka kwamalungu kunye ne-muscle atrophy zihlala zishiywe emva kokuba i-hematoma ifakwe ngenxa ye-synovitis ebangelwa ukuphuma kwegazi, okunempembelelo enkulu kwimpilo.Ukongeza, ukuhanjiswa kwe-intravascular coagulation, isifo esibi sesibindi kunye nezinye izifo ziya kubangela ukwanda okubonakalayo kwe-APTT, okuya kubangela ingozi ebonakalayo kumzimba womntu.
Ixabiso eliphezulu le-Apt libonisa ukuba isigulane sinokubandezeleka ngenxa yokuphazamiseka kwegazi.Iziphazamiso zokopha eziqhelekileyo ziquka ukunqongophala kwe-congenital coagulation factor kunye ne-hemophilia.Okwesibini, kurhanelwa ukuba kubangelwa sisifo sesibindi okanye i-jaundice ephazamisayo okanye isifo se-thrombotic.Kwakhona akuthintelwanga ukuba kubangelwa yimpembelelo yezinto zeziyobisi, ezifana nokusetyenziswa kwexesha elide leziyobisi ze-anticoagulant.Ngokonyango, uvavanyo lwe-apt lunokusetyenziswa ukugweba ukuba umsebenzi wokudibanisa emzimbeni wesigulana uqhelekile.Ukuba kungenxa yesiganeko esibangelwa yi-hemophilia, kuyacetyiswa ukuba ulandele iingcebiso zogqirha ukuyeka ukuphuma kwegazi okanye ukusebenzisa i-prothrombin unyango oluyinkimbinkimbi.