Unobangela osisiseko

1. Ukulimala kwe-cardiovascular endothelial
Ukulimala kweeseli ze-Vascular endothelial yeyona nto ibalulekileyo kunye neyona nto ibangela ukubunjwa kwe-thrombus, kwaye ixhaphake kakhulu kwi-endocarditis ye-rheumatic kunye ne-infective, izilonda ezinzima ze-atherosclerotic plaque, i-traumatic or inflammatory sites injury injury, njl. Kukho ne-hypoxia, ukothuka, i-sepsis kunye nebhaktheriya. i-endotoxins ebangela uluhlu olubanzi lwezifo ezingapheliyo kuwo wonke umzimba.
Emva kokulimala kwesikhumba, i-collagen phantsi kwe-endothelium ivuselela inkqubo yokudibanisa, ibangele ukusabalalisa i-intravascular coagulation, kunye neefom ze-thrombus kwi-microcirculation yomzimba wonke.

2. Ukuhamba kwegazi okungaqhelekanga
Ikakhulu ibhekisela ekunciphiseni ukuhamba kwegazi kunye nesizukulwana se-eddies ekuhambeni kwegazi, njl., kunye nezinto ezisebenzayo ze-coagulation kunye ne-thrombin zifikelela kugxininiso olufunekayo kwi-coagulation kwindawo yendawo, ehambelana nokubunjwa kwe-thrombus.Phakathi kwabo, i-veins iyancipha ngakumbi kwi-thrombus, exhaphake kakhulu kwizigulane ezinentliziyo, izifo ezingapheliyo kunye nokuphumla kwebhedi emva kokusebenza.Ukongezelela, ukuhamba kwegazi entliziyweni kunye nemithambo yegazi ngokukhawuleza, kwaye akulula ukwenza i-thrombus.Nangona kunjalo, xa igazi lihamba kwi-atrium yasekhohlo, i-aneurysm, okanye isebe lomthambo wegazi licotha kwaye i-eddy yangoku iyenzeka ngexesha le-mitral valve stenosis, iphinda ihlasele i-thrombosis.

3. Ukwandiswa kwe-coagulation yegazi
Ngokuqhelekileyo, iiplatelet kunye ne-coagulation factor in the blood increase, okanye umsebenzi we-fibrinolytic system uyancipha, okukhokelela kwi-hypercoagulable state egazini, exhaphake kakhulu kwi-hereditary kunye ne-hypercoagulable state.

4. I-Hereditary hypercoagulable state
Inxulumene ne-hereditary coagulation factor defects, iziphene zokuzalwa zeprotheni C kunye neprotheyini ye-S, njl. Phakathi kwazo, eyona nto ixhaphakileyo ye-V gene ukuguqulwa kwemfuza, izinga lokuguqulwa kwesi sitho sofuzo linokufikelela kwi-60% kwizigulane ezine-thrombosis enzulu ephindaphindiweyo.

5. I-hypercoagulable state efunyenweyo
Ngokuqhelekileyo kubonakala kumhlaza we-pancreatic, umhlaza wemiphunga, umhlaza webele, umhlaza wedlala lobudoda, umhlaza wesisu kunye nezinye izicubu ezinobungozi ze-metastatic eziphambili, ezibangelwa ukukhutshwa kwezinto ze-procoagulant ngamaseli omhlaza;inokuthi yenzeke kwintlungu enzima, ukutshisa okukhulu, utyando olukhulu okanye emva kokubeleka Kwimeko yokulahleka kwegazi okukhulu, kunye neemeko ezifana ne-gestational hypertension, i-hyperlipidemia, i-coronary atherosclerosis, ukutshaya, kunye nokukhuluphala.