Ngaphantsi kweemeko zomzimba, indima ye-thrombosis kukuyeka ukopha.Ukulungiswa kwazo naziphi na izihlunu kunye namalungu kufuneka kuqala kunqande ukopha.I-Hemophilia yi-coagulopathy ebangelwa kukungabikho kwezinto ezidibanisayo.Kunzima ukwenza i-thrombus kwindawo eyenzakeleyo kwaye ayikwazi ukumisa ngokufanelekileyo ukuphuma kwegazi kwaye kubangele ukopha.Uninzi lweefom ze-hemostatic thrombosis kwaye zikhona ngaphandle komthambo wegazi okanye apho umthambo wegazi uphukile.

Ukuba ihlwili legazi liyaba ngumthambo wegazi, ukuhamba kwegazi kumthambo wegazi kuyavaleka, ukuhamba kwegazi kuyancipha, okanye nokuhamba kwegazi kuyaphazamiseka.Ukuba i-thrombosis yenzeke kwi-arteries, iya kubangela i-organ / i-ischemia yezicubu kunye ne-necrosis, njenge-myocardial infarction, i-cerebral infarction, kunye ne-necrosis ephantsi / i-amputation.I-thrombus eyenziwe kwimithanjeni enzulu yemida engezantsi ayichaphazeli nje kuphela ukuhamba kwegazi le-venous entliziyweni kwaye ibangela ukudumba kweendawo ezisezantsi, kodwa iphinde iwele nge-inferior vena cava, i-atrium yasekunene kunye ne-ventricle yasekunene ukungena kunye nokuvalelwa ngaphakathi. Umthambo we-pulmonary, okhokelela kwi-pulmonary embolism.Izifo ezinamazinga aphezulu okufa.

Ukuqala kweThrombosis

Kwiimeko ezininzi, ikhonkco yokuqala ye-thrombosis yokulimala, enokuthi ibe yintlupheko, utyando, i-plaque rupture kwi-artery, okanye umonakalo ophelile obangelwa ukusuleleka, ukugonywa kunye nezinye izinto.Le nkqubo yokubunjwa kwe-thrombus eqalwe ngokulimala ibizwa ngokuba yi-exogenous coagulation system.Kwiimeko ezimbalwa, i-blood stasis okanye ukucotha kwegazi kunokuqalisa inkqubo ye-thrombosis, eyindlela yokunxibelelana, ebizwa ngokuba yi-endogenous coagulation system.

I-hemostasis yokuqala

Nje ukuba ukwenzakala kuchaphazele imithambo yegazi, iiplatelets ziqale zibambelele zenze umaleko omnye wokugquma inxeba, zize ke zisebenze ukuba zidibanise ukwenza i-clumps, eziyi-platelet thrombi.Yonke le nkqubo ibizwa ngokuba yiprimary hemostasis.

I-hemostasis yesibini

Ukwenzakala kukhupha into yokudibanisa ebizwa ngokuba yi-tissue factor, eqala inkqubo ye-endogenous coagulation ukuvelisa i-thrombin emva kokungena egazini.I-Thrombin ngokwenene yi-catalyst eguqula iprotein ye-coagulation egazini, oko kukuthi, i-fibrinogen ibe yi-fibrin., Yonke le nkqubo ibizwa ngokuba yi-hemostasis yesibini.

"Unxibelelwano olugqibeleleyo"I-Thrombosis

Kwinkqubo ye-thrombosis, isigaba sokuqala se-hemostasis (i-platelet adhesion, activation and aggregation) kunye nesigaba sesibini se-hemostasis (ukuveliswa kwe-thrombin kunye nokwakheka kwe-fibrin) ngokubambisana.I-hemostasis yenqanaba lesibini inokuqhutywa kuphela ngokuqhelekileyo phambi kweeplatelet, kwaye i-thrombin eyenziwe iqhubela phambili isebenze iiplatelet.Bobabini basebenza kunye kwaye basebenze kunye ukugqiba inkqubo ye-thrombosis.