Inkqubo yeThrombosis, kuquka iinkqubo ezi-2:

1. Ukunamathela kunye nokuhlanganiswa kweeplatelet egazini

Kwinqanaba lokuqala le-thrombosis, iiplatelet ziqhubeka zinyuka ukusuka kwi-axial flow kwaye zibambelela kumphezulu we-collagen fibers eveziweyo kwi-intima yemithambo yegazi eyonakalisiweyo.Iiplatelets zisebenza nge-collagen kwaye zikhupha izinto ezifana ne-ADP, i-thromboxane A2, i-5-AT kunye ne-platelet factor IV., Ezi zinto zinefuthe elinamandla le-agglutinating platelets, ukwenzela ukuba iiplatelet ezisegazini ziqhubeke zixubana kwindawo ukuze zenze ingqumba yeplatelet emile., ukuqala kwe-venous thrombosis, intloko ye-thrombus.

Iiplatelets zibambelela kumphezulu wemicu ye-collagen eveziweyo kwi-intima yomthambo wegazi owonakalisiweyo kwaye isebenze ukwenza i-hillock-like platelet stack.I-hillock ikhula ngokuthe ngcembe kwaye ixube kunye ne-leukocytes ukwenza i-thrombus emhlophe.Ineleukocyte ezininzi ezincanyathiselwe kumphezulu wayo.Ukuhamba kwegazi ngokuthe ngcembe kuyehla, inkqubo yokudibanisa iyasebenza, kwaye isixa esikhulu sefibrin senza isakhiwo sothungelwano, esibamba iiseli ezibomvu zegazi kunye neeseli ezimhlophe zegazi ukuze zenze i-thrombus edibeneyo.

2. Ukuqina kwegazi

Emva kokuba i-thrombus emhlophe yenziwe, iqhubela phambili kwi-lumen ye-vascular, ibangela ukuba igazi lihambe emva kwayo licothe kwaye libonakale liyi-whirlpool, kwaye i-platelet mound entsha yenziwa kwi-whirlpool.I-Trabeculae, efana ne-coral, ine-leukocyte ezininzi ezifakwe kumphezulu wazo.

Ukuhamba kwegazi phakathi kwe-trabeculae kuyancipha ngokuthe ngcembe, inkqubo yokudibanisa iyasebenza, kwaye ukuxinwa kwezinto ze-coagulation zendawo kunye ne-platelet factor inyuka ngokuthe ngcembe, ukwenza kunye nokudibanisa kwi-mesh structure phakathi kwe-trabeculae.Umhlophe kunye nomhlophe, i-thrombus edibeneyo edibeneyo eyenza umzimba we-thrombus.

I-thrombus exutywe ngokuthe ngcembe yanda kwaye yanda kwicala lokuhamba kwegazi, kwaye ekugqibeleni yavala ngokupheleleyo i-lumen yemithambo yegazi, ibangela ukuphuma kwegazi.