Kwabasetyhini abakhulelweyo abaqhelekileyo, ngokunyuka kwexesha lokukhulelwa, ukuphuma kwentliziyo kuyanda kwaye ukuchasana kwe-peripheral kuyancipha.Ngokuqhelekileyo kukholelwa ukuba imveliso yenhliziyo iqala ukunyuka kwi-8 ukuya kwiiveki ze-10 zokukhulelwa kwaye ifikelele kwincopho kwi-32 ukuya kwiiveki ze-34 zokukhulelwa, ukwanda kwe-30% ukuya kwi-45% xa kuthelekiswa nokungabikho kokukhulelwa, kwaye igcina eli nqanaba kude kube nokuzala.Ukuncipha kokunganyangeki kwemithambo yemithambo kunciphisa uxinzelelo lwemithambo, kwaye uxinzelelo lwegazi lwe-diastolic lwehla kakhulu, kwaye umahluko woxinzelelo lwe-pulse uyanda.Ukusukela kwiiveki ezi-6 ukuya kwezili-10 zokumitha, umthamo wegazi labasetyhini abakhulelweyo uyanda ngokwanda kwexesha lokumitha, kwaye unyuka malunga ne-40% ekupheleni kokukhulelwa, kodwa ukwanda komthamo we-plasma kudlula kakhulu inani leeseli ezibomvu zegazi, iplasma. inyuka nge-40% ukuya kwi-50%, kwaye iiseli ezibomvu zegazi zonyuka nge-10% ukuya kwi-15%.Ngoko ke, ekukhulelweni okuqhelekileyo, igazi lihlanjululwe, libonakaliswe njengokuncipha kwe-viscosity yegazi, ukunciphisa i-hematocrit, kunye nokunyuka kwe-erythrocyte sedimentation rate.

Imiba ye-blood coagulation Ⅱ, Ⅴ, VII, Ⅷ, IX, kunye ne-Ⅹ yonke inyuka ngexesha lokukhulelwa, kwaye inokufikelela kwi-1.5 ukuya ku-2.0 amaxesha aqhelekileyo phakathi nokukhulelwa kwexesha eliphakathi, kunye nemisebenzi ye-coagulation factor Ⅺ kunye ne- iyancipha.I-Fibrinopeptide A, i-fibrinopeptide B, i-thrombinogen, i-platelet factor Ⅳ kunye ne-fibrinogen yanda kakhulu, ngelixa i-antithrombin Ⅲ kunye neprotheni C kunye neprotheni S yehla.Ngexesha lokukhulelwa, ixesha le-prothrombin kunye nexesha elisebenzayo leprothrombin lifutshane, kwaye umxholo we-plasma fibrinogen uyanda kakhulu, onokunyuka ukuya kwi-4-6 g / L kwi-trimester yesithathu, malunga ne-50% ephezulu kunomntu ongakhulelwanga. ixesha.Ukongezelela, i-plasminogen yanda, ixesha lokuchithwa kwe-euglobulin lahlala ixesha elide, kwaye utshintsho lwe-coagulation-anticoagulation lwenze umzimba kwi-hypercoagulable state, eyayinenzuzo kwi-hemostasis esebenzayo emva kokuphazamiseka kwe-placenta ngexesha lomsebenzi.Ukongezelela, ezinye izinto ezibangelwa yi-hypercoagulable ngexesha lokukhulelwa ziquka ukunyuka kwe-cholesterol epheleleyo, i-phospholipids kunye ne-triacylglycerols egazini, i-androgen kunye ne-progesterone efihliweyo yi-placenta inciphisa umphumo we-blood coagulation inhibitors, i-placenta, i-uterine decidua kunye ne-embryos.Ubukho bezinto ze-thromboplastin, njl., zinokukhuthaza igazi ukuba libe kwimeko ye-hypercoagulable, kwaye olu tshintsho lugqithiswa ngokunyuka kwexesha lokukhulelwa.I-hypercoagulation ephakathi yindlela yokukhusela i-physiological , enenzuzo yokugcina i-fibrin deposition kwi-arteries, udonga lwesibeleko kunye ne-placental villi, inceda ukugcina ingqibelelo ye-placenta kunye nefom ye-thrombus ngenxa yokuhluthwa, kunye nokuququzelela i-hemostasis ngokukhawuleza ngexesha nangemva kokunikezelwa., yindlela ebalulekileyo yokuthintela ukuphuma kwegazi emva kokubeleka.Ngexesha elifanayo le-coagulation, umsebenzi wesibini we-fibrinolytic uqala ukucima i-thrombus kwi-uterine spiral arteries kunye ne-venous sinuses kunye nokukhawulezisa ukuvuselelwa nokulungiswa kwe-endometrium.