Abaphandi kwiYunivesithi yaseMonash baye baqulunqa i-antibody entsha enokuthintela iprotheyini ethile egazini ukukhusela i-thrombosis ngaphandle kwemiphumo emibi.Le antibody inokuthintela i-thrombosis ye-pathological, enokubangela ukuhlaselwa kwentliziyo kunye nokubetha ngaphandle kokuchaphazela umsebenzi oqhelekileyo wokuvala igazi.

Ukuhlaselwa sisifo sentliziyo kunye nestroke zihlala zingoonobangela abaphambili bokubhubha kunye nezigulo kwihlabathi liphela.Unyango lwangoku lwe-antithrombotic (anticoagulant) lunokubangela kwaye lubangele iingxaki ezinzulu zokopha kuba zikwaphazamisana negazi eliqhelekileyo.Isine kwisihlanu sezigulana ezifumana unyango lwe-antiplatelet ziseneziganeko ze-cardiovascular eziqhubekayo.

Ngoko ke, amachiza akhoyo e-antiplatelet akanakusetyenziswa kwiidosi ezinkulu.Ke ngoko, ukusebenza kweklinikhi kusekudanisa, kwaye unyango lwexesha elizayo kufuneka luhlengahlengiswe ngokusisiseko.

Indlela yophando kukuqala ukumisela umahluko webhayoloji phakathi kokuqina okuqhelekileyo kunye ne-pathological coagulation, kwaye ufumanise ukuba i-von Willebrand factor (VWF) itshintsha iipropathi zayo xa i-thrombus eyingozi yenziwa.Uphononongo lwenze i-antibody efumanisa kuphela kwaye ithintele le fomu ye-VWF ye-pathological, kuba isebenza kuphela xa ihlwili legazi liba yi-pathological.

Uphononongo luhlalutye iimpawu ze-anti-VWF esele zikhona kwaye zamisela ezona mpawu zibalaseleyo ze-antibody nganye ukuba zibophe kwaye zithintele i-VWF phantsi kweemeko ze-pathological coagulation.Xa kungekho nakuphi na ukusabela okubi, ezi zilwa-buhlungu ezinokuthi zibe kho ziqale zidityaniswe zibe yinkqubo entsha yegazi ukuthintela ezi ngxaki zinokwenzeka.

Oogqirha ngoku bajongene nolungelelwaniso olubuthathaka phakathi kokusebenza kwechiza kunye neziphumo ebezingalindelekanga ukopha.I-antibody eyenziwe ngobunjineli iyilwe ngokukodwa kwaye ayiyi kuphazamisana negazi eliqhelekileyo, ngoko ke kuyathenjwa ukuba inokusebenzisa idosi ephezulu kunye nesebenzayo kunonyango olukhoyo.

Olu phononongo lwe-in vitro lwenziwe ngeesampulu zegazi lomntu.Inyathelo elilandelayo kukuvavanya ukusebenza kakuhle kwe-antibody kwimodeli yezilwanyana ezincinci ukuqonda indlela esebenza ngayo kwinkqubo yokuphila entsonkothileyo efana neyethu.

Isalathiso: UThomas Hoefer et al.Ukujolisa kwithagethi ye-shear eyenziwe yasebenza i-von Willebrand factor yinoveli ye-antibody ye-single-chain A1 yehlisa ukwakheka kwe-occlusive thrombus kwi-vitro, i-Haematologica (2020).