Inoveli ye-2019 ye-coronavirus pneumonia (COVID-19) isasazeke kwihlabathi jikelele.Uphononongo lwangaphambili lubonise ukuba usulelo lwe-coronavirus lunokukhokelela kukuphazamiseka kwe-coagulation, ngakumbi kubonakaliswa njengexesha elide elisebenzayo le-thromboplastin (APTT), i-thrombocytopenia, i-D-dimer (DD) Amanqanaba aphezulu kunye nokusasazwa kwe-intravascular coagulation (DIC), ehambelana nokufa okuphezulu.

Uhlalutyo lwamva nje lwe-meta-coagulation kwizigulana ezine-COVID-19 (kubandakanywa nezifundo ezili-9 ezibuyela emva kunye nezigulana ezili-1 105 zizonke) zibonise ukuba xa kuthelekiswa nezigulana ezithambileyo, izigulana eziqatha ze-COVID-19 zinexabiso eliphezulu kakhulu le-DD, ixesha leProthrombin (PT) yayinde;ukwanda kweDD kwaba ngumngcipheko wokunyuka kunye nomngcipheko wokufa.Nangona kunjalo, uhlalutyo lwe-Meta olukhankanywe ngasentla lubandakanya izifundo ezimbalwa kwaye lubandakanya izifundo ezimbalwa zophando.Kutshanje, izifundo zeklinikhi ezinkulu ngakumbi malunga nokusebenza kwe-coagulation kwizigulana ezine-COVID-19 zipapashiwe, kwaye iimpawu zokudityaniswa kwezigulana ezine-COVID-19 ezixelwe kwizifundo ezahlukeneyo nazo azikho ncam.

Uphononongo lwakutsha nje olusekwe kwidatha yesizwe lubonise ukuba iipesenti ezingama-40 zabaguli be-COVID-19 basemngciphekweni omkhulu we-venous thromboembolism (VTE), kwaye i-11% yezigulana ezisemngciphekweni omkhulu zikhula ngaphandle kwamanyathelo othintelo.VTE.Iziphumo zolunye uphononongo zikwabonise ukuba i-25% yezigulana ezinzima ze-COVID-19 zaphuhlisa i-VTE, kwaye izinga lokusweleka kwezigulana ezine-VTE laliphezulu ukuya kuma-40%.Ibonisa ukuba abaguli abane-COVID-19, ngakumbi abaguli kakhulu okanye abagula kakhulu, banomngcipheko ophezulu we-VTE.Isizathu esinokwenzeka kukuba izigulana ezinobunzima kunye nezigulayo zinezifo ezingaphezulu, ezifana nembali ye-cerebral infarction kunye ne-tumor eyingozi, zonke ziyimingcipheko ye-VTE, kunye nezigulana ezinzima kunye nezigula kakhulu zilele ebhedini ixesha elide, zihlalisiwe, zingenakunyakaziswa. , kwaye ibekwe kwizixhobo ezahlukeneyo.Amanyathelo onyango afana neetyhubhu nazo ziyimingcipheko ye-thrombosis.Ke ngoko, kwizigulana ze-COVID-19 ezimandundu nezigula kakhulu, uthintelo ngoomatshini lwe-VTE, olufana neekawusi ezilastiki, impompo evuthelweyo engapheliyo, njl.njl., inokwenziwa;ngelo xesha, imbali yonyango edlulileyo yesigulane kufuneka iqondwe ngokupheleleyo, kwaye umsebenzi we-coagulation wesigulane kufuneka uhlolwe ngexesha elifanelekileyo.kwizigulane, i-prophylactic anticoagulation inokuqaliswa ukuba akukho zichaso

Iziphumo zangoku zibonisa ukuba ukuphazamiseka kwe-coagulation kuxhaphake kakhulu kwizigulana ezinzima, ezigula kakhulu, kunye nezigulayo ze-COVID-19.Ukubalwa kwePlatelet, iDD kunye ne-PT amaxabiso anxulunyaniswa nobunzima besifo kwaye anokusetyenziswa njengezalathisi zokulumkisa kwangaphambili zokuwohloka kwesifo ngexesha lokulaliswa esibhedlele.