Xa ukungasebenzi kakuhle kwe-coagulation yesigulana kukhokelela ekopheni, kunokubangelwa kukuncipha kokusebenza kwe-coagulation.Uvavanyo lwe-coagulation factor luyafuneka.Kucacile ukuba ukopha kubangelwa ukunqongophala kwezinto zokudibanisa okanye izinto ezininzi zokulwa ne-anticoagulation.Ngokwesizathu, yongeza izinto ezihambelana ne-coagulation okanye iplasma entsha.Ubukho bezinto ezininzi zokujiyisa bunokunceda ukuyeka ukopha.Ngokweklinikhi, kunokubonwa ukuba ngaba izinto ezihambelanayo zokudibanisa iindlela zangaphakathi kunye nezangaphandle ze-coagulation ze-coagulation ziyancipha okanye zingasebenzi kakuhle, kwaye zikhangele ukuba umsebenzi we-coagulation ongaqhelekanga ubangelwa ukungabikho kwezinto ezidibeneyo okanye umsebenzi wezinto ezidibeneyo, ngokukodwa. kuquka le miqathango ilandelayo:

1. Indlela ye-endogenous coagulation engaqhelekanga: Eyona nto iphambili yokudibanisa i-endogenous coagulation pathway yi-APTT.Ukuba i-APTT ithatha ixesha elide, ithetha ukuba kukho izinto ezingaqhelekanga ze-coagulation kwindlela engapheliyo, njenge-factor 12, factor 9, factor 8, kunye ne-common pathway 10. Ukusilela kwezinto kunokubangela iimpawu zokuphuma kwegazi kwizigulane;

2. Indlela engaqhelekanga ye-coagulation yangaphandle: ukuba i-PT ithatha ixesha elide, inokubonwa ukuba i-tissue factor, i-5 kunye ne-10 kwindlela eqhelekileyo ingaba yinto engavamile, oko kukuthi, ukuncipha kwenani kukhokelela kwixesha elide lokuxhamla kwaye kubangela ukuphuma kwegazi. kwisigulana.