I-Thrombosis idla ngokuba nezi meko zintathu zilandelayo:

1. Intliziyo kunye nemithambo yegazi ukwenzakala intima

I-intima yentliziyo eqhelekileyo kunye nemithambo yegazi ayichanekanga kwaye igudile, kwaye iiseli ze-endothelial ezingaguqukiyo zinokunqanda ukunamathela kweplatelet kunye ne-anticoagulation.Xa i-membrane yangaphakathi yonakalisiwe, inkqubo ye-coagulation ingenziwa ngeendlela ezininzi.

I-intima yokuqala eyonakalisiweyo ikhupha i-tissue coagulation factor (i-coagulation factor III), eyenza i-extrinsic coagulation system.
Okwesibini, emva kokuba i-intima yonakaliswe, iiseli ze-endothelial zihlanjululwa, i-necrosis, kunye nokuchithwa, ziveze iifibers ze-collagen phantsi kwe-endothelium, ngaloo ndlela isebenze i-coagulation factor XII ye-endogenous coagulation system kunye nokuqala inkqubo yokudibanisa engapheliyo.Ukongeza, i-intima eyonakalisiweyo iba rhabaxa, ehambelana neplatelet deposition kunye nokubambelela.Emva kokuqhekeka kweeplatelet ezinamathele, iintlobo ezahlukeneyo zeplatelet zikhutshwa, kwaye yonke inkqubo ye-coagulation ivuliwe, ibangela ukuba igazi lidibanise kwaye lenze i-thrombus.
Izinto ezahlukeneyo zomzimba, iikhemikhali kunye nebhayoloji zinokubangela umonakalo kwi-intima ye-cardiovascular, njenge-endocarditis kwi-erysipelas yehagu, i-pulmonary vasculitis kwi-pneumonia yenkomo, i-equine parasitic arteritis, iinaliti eziphindaphindiweyo kwindawo enye ye-vein, Ukulimala kunye nokuhlatywa kodonga lwegazi. ngexesha lotyando.

2. Utshintsho kwisimo sokuhamba kwegazi

Ikakhulu ibhekisa ekuhambeni okucothayo kwegazi, ukwakheka kwe-vortex kunye nokuyeka ukuhamba kwegazi.
Ngaphantsi kweemeko eziqhelekileyo, izinga lokuhamba kwegazi likhawuleza, kwaye iiseli ezibomvu zegazi, iiplatelet kunye nezinye izinto zigxininiswe kumbindi wegazi, obizwa ngokuba yi-axial flow;xa izinga lokuhamba kwegazi liyehla, iiseli ezibomvu zegazi kunye neeplatelet ziya kuhamba kufuphi nodonga lwegazi, olubizwa ngokuba yi-side flow, okwandisa i-thrombosis.umngcipheko ovelayo.
Ukuhamba kwegazi kuyancipha, kwaye iiseli ze-endothelial zine-hypoxic kakhulu, ezibangela ukuhla kunye necrosis yeeseli ze-endothelial, ukulahlekelwa ngumsebenzi wabo wokudibanisa kunye nokukhupha izinto ezichasene ne-anticoagulant, kunye nokuvezwa kwe-collagen, eyenza inkqubo ye-coagulation isebenze kwaye ikhuthaze. i-thrombosis.
Ukuhamba kwegazi okucothayo nako kunokwenza i-thrombus eyenziwe lula ukuyilungisa eludongeni lwemithambo yegazi kwaye iqhubeke nokukhula.

Ngoko ke, i-thrombus idla ngokuvela emithanjeni ehamba ngokucotha kwegazi kunye ne-eddy currents (kwii-valve ze-venous).Ukuhamba kwegazi kwe-aortic kukhawuleza, kwaye i-thrombus ayibonakali ngokungaqhelekanga.Ngokwezibalo, ukwenzeka kwe-venous thrombosis ngamaxesha angama-4 ngaphezu kwe-thrombosis ye-arterial, kwaye i-thrombosis ye-venous ivame ukuvela kwintliziyo, emva kokuhlinzwa okanye kwizilwanyana ezigulayo ezilele kwidleke ixesha elide.
Ngoko ke, kubaluleke kakhulu ukunceda izilwanyana ezigulayo ezilele phantsi ixesha elide kwaye emva kokuhlinzwa ukwenza imisebenzi efanelekileyo ukukhusela i-thrombosis.
3. Utshintsho kwiimpawu zegazi.

Ikakhulu ibhekisa ekunyukeni kwegazi.Okufana nokutshisa okubanzi, ukuphelelwa ngamanzi emzimbeni, njl njl ukugxila kwigazi, ukwenzakala kakhulu, emva kokubeleka, kunye nokulahlekelwa kakhulu kwegazi emva kokuhlinzwa okukhulu kunokunyusa inani leeplatelet egazini, ukwandisa i-viscosity yegazi, kunye nokwandisa umxholo we-fibrinogen, i-thrombin kunye nezinye izinto ezidibeneyo. kwiplasma Ukwanda.Ezi zinto zinokukhuthaza i-thrombosis.