Kuyenzeka ukwazi ukuba ngaba isigulana sinomsebenzi ongaqhelekanga we-coagulation phambi kotyando, ukuthintela ngokufanelekileyo iimeko ezingalindelekanga ezifana nokopha okungayekiyo ngexesha nasemva kotyando, ukuze ufumane esona siphumo sotyando.
Umsebenzi we-hemostatic womzimba ufezekiswa ngokudibeneyo kweeplatelet, inkqubo ye-coagulation, inkqubo ye-fibrinolytic kunye ne-vascular endothelial system.Kwixesha elidlulileyo, sasisebenzisa ixesha lokuphuma kwegazi njengovavanyo lokuhlola iziphene ze-hemostatic function, kodwa ngenxa yomgangatho ophantsi, ubuthathaka obuthathaka, kunye nokungakwazi ukubonakalisa umxholo kunye nomsebenzi we-coagulation factor, ithathelwe indawo ngovavanyo lomsebenzi we-coagulation.Iimvavanyo zomsebenzi we-Coagulation ikakhulu zibandakanya ixesha le-plasma prothrombin (PT) kunye nomsebenzi we-PT obalwa ukusuka kwi-PT, umlinganiselo wamazwe ngamazwe oqhelekileyo (INR), i-fibrinogen (FIB), i-activated partial thromboplastin time (APTT) kunye nexesha le-plasma thrombin (TT).
I-PT ibonisa kakhulu umsebenzi we-extrinsic coagulation system.Ixesha elide le-PT libonwa ikakhulu kwi-congenital coagulation factor II, V, VII, kunye ne-X yokunciphisa, ukunqongophala kwe-fibrinogen, ukufumana i-coagulation factor deficiency (DIC, i-primary hyperfibrinolysis, i-jaundice obstructive, ukungabikho kwe-vitamin K, kunye ne-anticoagulant substances kwi-circulation yegazi. Ikakhulu ibonakala kwi-congenital coagulation factor V ukwanda, i-DIC yokuqala, izifo ze-thrombotic, izicwangcisi zomlomo, njl.
I-APTT lolona vavanyo luthembekileyo lokuhlola ukunqongophala kwento ye-coagulation engapheliyo.I-APTT yexesha elide ibonakala ikakhulu kwi-hemophilia, i-DIC, isifo sesibindi, kunye notofelo-gazi olukhulu lwebhanki.I-APTT emfutshane ibonakala kakhulu kwi-DIC, i-prothrombotic state, kunye nezifo ze-thrombotic.I-APTT ingasetyenziswa njengesalathisi sonyango lwe-heparin.
Ukwandiswa kwe-TT kubonakala kwi-hypofibrinogenemia kunye ne-dysfibrinogenemia, ukunyuka kwe-FDP egazini (DIC), kunye nobukho be-heparin kunye ne-heparinoid izinto egazini (umzekelo, ngexesha lonyango lwe-heparin, i-SLE, isifo sesibindi, njl.).
Kwakukho isigulane esiphuthumayo esafumana iimvavanyo zebhubhoratri zangaphambili, kwaye iziphumo zovavanyo lwe-coagulation zaye zathatha ixesha elide i-PT kunye ne-APTT, kwaye i-DIC yakrokrelwa kwisigulane.Ngaphantsi kwengcebiso yebhubhoratri, isigulane safumana uluhlu lweemvavanyo ze-DIC kwaye iziphumo zilungile.Akukho zimpawu zicacileyo ze-DIC.Ukuba isigulane asinalo uvavanyo lwe-coagulation, kunye nokuhlinzwa ngokuthe ngqo, iziphumo ziya kuba yintlekele.Uninzi lweengxaki ezinjalo zinokufunyanwa kuvavanyo lomsebenzi we-coagulation, othe wathenga ixesha elingakumbi lokufunyanwa kweklinikhi kunye nonyango lwezifo.Uvavanyo lothotho lwe-Coagulation luvavanyo olubalulekileyo lwebhubhoratri yomsebenzi we-coagulation yezigulana, ezinokubona umsebenzi ongaqhelekanga wokuqina kwizigulana phambi kotyando, kwaye kufuneka ihlawulwe ingqwalasela eyaneleyo.
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