Umzimba oqhelekileyo unenkqubo epheleleyo ye-coagulation kunye ne-anticoagulation.Inkqubo ye-coagulation kunye ne-anticoagulation system igcina ibhalansi eguquguqukayo ukuqinisekisa i-hemostasis yomzimba kunye nokuhamba kwegazi okugudileyo.Emva kokuba i-coagulation kunye ne-anticoagulation ibhalansi yokusebenza iphazamisekile, iya kubangela ukopha kunye nokuthambekela kwe-thrombosis.

1. Umsebenzi we-coagulation womzimba

Inkqubo ye-coagulation iqulunqwe kakhulu yimiba yokudibanisa.Izinto ezibandakanyeka ngokuthe ngqo kwi-coagulation zibizwa ngokuba yi-coagulation factor.Kukho izinto ezili-13 ezaziwayo zokudibanisa.

Kukho iindlela zokuvula ezingapheliyo kunye neendlela eziphuma ngaphandle zokuvula i-coagulation factor.

Okwangoku kukholelwa ukuba ukusetyenziswa kwenkqubo ye-coagulation exogenous eqalwe yi-tissue factor idlala indima enkulu ekuqaliseni ukudibanisa.Uxhulumaniso olusondeleyo phakathi kweenkqubo zangaphakathi kunye nezangaphandle zokudibanisa zidlala indima ebalulekileyo ekuqaliseni nasekugcineni inkqubo yokudibanisa.

2. Umsebenzi we-anticoagulant womzimba

Inkqubo ye-Anticoagulation ibandakanya inkqubo ye-anticoagulation yeselula kunye nenkqubo ye-anticoagulation yomzimba.

①Inkqubo ye-Cell anticoagulation

Ibhekisela kwi-phagocytosis ye-coagulation factor, i-tissue factor, i-prothrombin eyinkimbinkimbi kunye ne-soluble fibrin monomer yinkqubo ye-mononuclear-phagocyte.

②Inkqubo ye-anticoagulation yomzimba

Kubandakanywa: i-serine protease inhibitors, i-protein C-based protease inhibitors kunye ne-tissue factor pathway inhibitors (TFPI).

3. Inkqubo yeFibrinolytic kunye nemisebenzi yayo

Ngokukodwa ziquka i-plasminogen, i-plasmin, i-activator ye-plasminogen kunye ne-fibrinolysis inhibitor.

Indima yenkqubo ye-fibrinolytic: nyibilikisa i-fibrin clots kwaye uqinisekise ukuhamba kakuhle kwegazi;inxaxheba ekulungiseni izicubu kunye nokuvuselelwa kwe-vascular.

4. Indima yeeseli ze-vascular endothelial kwinkqubo ye-coagulation, i-anticoagulation kunye ne-fibrinolysis.

① Ukuvelisa izinto ezahlukeneyo zebhayoloji esebenzayo;

②Ukulawula ukudibanisa kwegazi kunye nomsebenzi we-anticoagulation;

③Lungisa umsebenzi wenkqubo ye-fibrinolysis;

④ Ukulawula uxinzelelo lwe-vascular;

⑤Thatha inxaxheba kulamlo lokudumba;

⑥Gcina umsebenzi we-microcirculation, njl.

I-Coagulation kunye nokuphazamiseka kwe-anticoagulant

1. Ukungaqhelekanga kwimiba ye-coagulation.

2. Ukungahambi kakuhle kwezinto ze-anticoagulant kwi-plasma.

3. Ukungahambi kakuhle kwe-fibrinolytic factor kwi-plasma.

4. Ukungaqhelekanga kweeseli zegazi.

5. Imithambo yegazi engaqhelekanga.