Ixesha leProthrombin (PT) liyisalathisi esibaluleke kakhulu sokubonisa umsebenzi wesibindi, ukugcinwa komsebenzi, ubunzima besifo kunye ne-prognosis.Okwangoku, ukuxilongwa kweklinikhi yezinto ezidibeneyo kuye kwaba yinyani, kwaye kuya kunika ulwazi olungaphambili kunye nolwazi oluchanekileyo kune-PT ekugwebeni imeko yesifo sesibindi.

Ukusetyenziswa kweklinikhi ye-PT kwisifo sesibindi:

Ilabhoratri ibika i-PT ngeendlela ezine: iprothrombintime activitypercentagePTA (prothrombin time ratio PTR) kunye ne-international normalized ratio INR.Iifom ezine zinemilinganiselo eyahlukeneyo yesicelo seklinikhi.

Ixabiso lesicelo se-PT kwisifo sesibindi: I-PT inqunywe ngokukodwa kwinqanaba le-coagulation factor IIvX eyenziwe yisibindi, kwaye indima yayo kwisifo sesibindi ibaluleke kakhulu.Izinga elingaqhelekanga le-PT kwi-hepatitis enzima yayiyi-10% -15%, i-hepatitis engapheliyo yayingu-15% -51%, i-cirrhosis yayingu-71%, kunye ne-hepatitis enzima yi-90%.Kwindlela yokuxilonga ye-viral hepatitis ngo-2000, i-PTA yenye yezibonakaliso zekliniki yezigulane ezine-hepatitis yentsholongwane.Izigulane ze-hepatitis yentsholongwane engapheliyo kunye ne-PTA emnene> 70%, i-70% -60% ephakathi, i-60% -40% enzima;i-cirrhosis enenqanaba lembuyekezo ye-PTA>i-60% yenqanaba lokuthotywa kwe-PTA <60%;i-hepatitis enzima ye-PTA <40%" Kuluhlu lwe-Child-Pugh, i-1 inqaku le-PT yokwandisa i-1 ~ 4s, amanqaku ama-2 kwi-4 ~ 6s, amanqaku ama-3 kwi-> 6s, edibene nezinye izibonakaliso ze-4 (i-albumin, i-bilirubin, i-ascites, i-encephalopathy ), umsebenzi wesibindi wezigulane ezinesifo sesibindi Ii-Reserves zihlulwe zibe ngamanqanaba e-ABC; inqaku le-MELD (i-Modelfor end-stageliver disease), emisela ubunzulu besifo kwizigulane ezinesigaba sokugqibela sesifo kunye nokulandelelana kokutshintshwa kwesibindi, ifomula ithi .8xloge[bilirubin(mg/dl)+11.2xloge(INR)+ 9.6xloge[creatinine (mg/dl]+6.4x (isizathu: i-biliary okanye i-alcohol 0; enye i-1), i-INR yenye yezalathi ezi-3.

Iikhrayitheriya zokuxilonga ze-DIC zesifo sesibindi zibandakanya: Ukwandiswa kwe-PT ngaphezu kwe-5 okanye i-activated partial thromboplastin time (APTT) ngaphezu kwe-10s, umsebenzi we-factor VIII <50% (efunekayo);I-PT kunye ne-platelet count zihlala zisetyenziselwa ukuvavanya i-biopsy yesibindi kunye notyando Ukuthambekela ukopha kwezigulane, ezifana neeplatelet <50x10 ° / L, kunye ne-PT yokwandisa ixesha elingaphezu kwesiqhelo kwi-4s zichasene ne-biopsy yesibindi kunye notyando olubandakanya ukutshintshwa kwesibindi.Ingabonwa ukuba i-PT idlala indima ebalulekileyo ekuxilongweni nasekunyangweni kwezigulane ezinesifo sesibindi.