Thrombosis le hemostasis ke mesebetsi ea bohlokoa ea 'mele oa motho, e kenyelletsang methapo ea mali, liplatelete, mabaka a ho kopanya, liprotheine tsa anticoagulant le sistimi ea fibrinolytic.Ke sehlopha sa litsamaiso tse leka-lekaneng hantle tse netefatsang phallo e tloaelehileng ea mali 'meleng oa motho.Ho potoloha ho sa khaotseng ha phallo, ha ho tšolloe ho tsoa mothapong oa mali (hemorrhage) kapa ho hoama ho mothapo oa mali (thrombosis).

Mochine oa thrombosis le hemostasis hangata o arotsoe ka mehato e meraro:

Hemostasis ea pele e ameha haholo leboteng la sekepe, lisele tsa endothelial le liplatelete.Ka mor'a kotsi ea sekepe, liplatelete li bokana ka potlako ho emisa ho tsoa mali.

Secondary hemostasis, eo hape e tsejoang e le plasma hemostasis, e kenya tšebetsong sistimi ea coagulation ho fetolela fibrinogen ho insoluble cross-linked fibrin, e etsang maqeba a maholo.

Fibrinolysis, e senyang lesela la fibrin le ho khutlisetsa phallo e tloaelehileng ea mali.

Mohato o mong le o mong o laoloa ka nepo ho boloka boemo bo leka-lekaneng.Mefokolo ho sehokelo sefe kapa sefe ho tla lebisa mafung a amanang.

Mathata a ho tsoa mali ke lentsoe le akaretsang bakeng sa mafu a bakoang ke mekhoa e sa tloaelehang ea hemostasis.Mathata a ho tsoa mali a ka aroloa ka mekhahlelo e 'meli: a lefutso le a fumanoang, 'me lipontšo tsa kliniki haholo-holo li tsoa mali likarolong tse fapaneng.Mathata a ho tsoa mali a Congenital, hemophilia e tloaelehileng A (khaello ea coagulation factor VIII), haemophilia B (ho haella ha coagulation factor IX) le ho se tloaelehe ha coagulation ho bakoang ke khaello ea fibrinogen;mathata a ho tsoa mali a fumanoeng, a tloaelehileng Ho na le khaello ea vithamine K e itšetlehileng ka coagulation factor, mabaka a sa tloaelehang a coagulation a bakoang ke lefu la sebete, joalo-joalo.

Mafu a thromboembolic a arotsoe haholo ka arterial thrombosis le venous thromboembolism (venousthromboembolism, VTE).Arterial thrombosis e tloaelehile haholo methapong ea mali, methapo ea boko, methapo ea mesenteric, le methapo ea maoto, joalo-joalo Ho qala hangata ka tšohanyetso, 'me bohloko bo boholo ba sebakeng seo bo ka' na ba etsahala, joalo ka angina pectoris, bohloko ba ka mpeng, bohloko bo boholo maotong, joalo-joalo. ;e bakoa ke lefu la ischemia le hypoxia likarolong tse amehang tsa phepelo ea mali Setho se sa tloaelehang, sebopeho sa lisele le ts'ebetso, joalo ka infarction ea myocardial, ho hloleha ha pelo, letsoalo la pelo, arrhythmia, tšitiso ea kelello le hemiplegia, joalo-joalo;ho tsoa ha thrombus ho baka embolism ea cerebral embolism, renal embolism, splenic embolism le matšoao le matšoao a mang a amanang.Venous thrombosis ke mofuta o atileng haholo oa thrombosis e tebileng ea methapo e tlase.E tloaelehile methapong e tebileng e kang popliteal vein, femoral vein, mesenteric vein, le portal vein.Lipontšo tse utloahalang ke ho ruruha ha sebaka le botenya bo sa tsitsang ba likarolo tse tlaase.Thromboembolism e bolela ho koaleha ha thrombus sebakeng sa sebopeho, ho thibela ka mokhoa o itseng kapa ka botlalo methapo e meng ea mali nakong ea ho tsamaea le phallo ea mali, ho baka ischemia, hypoxia, necrosis (arterial thrombosis) le congestion, edema ( pathological process of venous thrombosis). .Ka mor'a hore thrombosis ea methapo e tebileng ea karolo e ka tlaase e theohe, e ka kena mothapong oa pulmonary ka ho potoloha ha mali, 'me matšoao le matšoao a pulmonary embolism a hlaha.Ka hona, thibelo ea venous thromboembolism ke ea bohlokoa haholo.