Bohlokoa ba bongaka
Ha e le hantle e na le moelelo o tšoanang le oa nako ea coagulation, empa ka kutloisiso e phahameng.Boholo ba mekhoa ea ho etsa qeto ea APTT e sebelisoang hajoale e ka ba e sa tloaelehang ha karolo ea plasma coagulation e le tlase ho 15% ho isa ho 30% ea boemo bo tloaelehileng.
(1) Ho lelefatsa APTT: sephetho sa APTT se bolelele ba metsotsoana ea 10 ho feta ea taolo e tloaelehileng.APTT ke tlhahlobo e tšepahalang ka ho fetisisa ea tlhahlobo ea khaello ea endogenous coagulation factor mme e sebelisoa haholo ho sibolla hemophilia e bobebe.Leha ntlha ea Ⅷ: Maemo a C a ka bonoa ka tlase ho 25% ea haemophilia A, kutloelo-bohloko ho subclinical hemophilia (factor Ⅷ>25%) le bajari ba haemophilia e fokola.Liphetho tsa nako e telele li boetse li bonoa ho factor Ⅸ (hemophilia B), Ⅺ le Ⅶ mefokolo;ha mali a anticoagulant lintho tse kang coagulation factor inhibitors kapa maemo a heparin a eketseha, prothrombin, fibrinogen le factor V, khaello ea X le eona E ka ba nako e telele, empa kutlo e fokola hanyane;Ho lelefatsa APTT ho ka boela ha bonoa ho bakuli ba bang ba tšoeroeng ke lefu la sebete, DIC, le mali a mangata a banka.
(2) khutsufatso ea APTT: e bonoa ho DIC, boemo ba prethrombotic le lefu la thrombotic.
(3) Tlhokomelo ea kalafo ea heparin: APTT e na le kutloelo-bohloko haholo ho bongata ba plasma ea heparin, ka hona ke index ea tlhahlobo ea laboratori e sebelisoang haholo hajoale.Ka nako ena, hoa lokela ho hlokomeloa hore sephetho sa tekanyo ea APTT se tlameha ho ba le kamano e haufi le bongata ba plasma ea heparin molemong oa kalafo, ho seng joalo ha ea lokela ho sebelisoa.Ka kakaretso, nakong ea kalafo ea heparin, ho eletsoa ho boloka APTT ka makhetlo a 1.5 ho isa ho a 3.0 ho feta a taolo e tloaelehileng.
Tlhahlobo ea sephetho
Hangata, APTT le PT li sebelisoa e le liteko tsa tlhahlobo ea tšebetso ea mali a coagulation.Ho latela liphetho tsa litekanyo, ho na le maemo a ka bang mane a latelang:
(1) Ka bobeli APTT le PT li tloaelehile: Ntle le batho ba tloaelehileng, e bonoa feela ka ho haelloa ke lefutso le la bobeli la FXIII.Tse fumanweng li tloaelehile ho lefu le matla la sebete, hlahala ea sebete, malignant lymphoma, leukemia, anti-factor XIII antibody, autoimmune anemia le pernicious anemia.
(2) APTT ea nako e telele e nang le PT e tloaelehileng: Boholo ba mathata a ho tsoa mali a bakoa ke bofokoli tseleng ea intrinsic coagulation.Joalo ka haemophilia A, B, le khaello ea factor Ⅺ;ho na le li-anti-factor Ⅷ, Ⅸ, Ⅺ li-antibodies maling.
(3) APTT e tloaelehileng e nang le nako e telele ea PT: mathata a mangata a ho tsoa mali a bakoang ke bokooa tseleng ea extrinsic coagulation, e kang ho haelloa ke liphatsa tsa lefutso le tse fumanoeng factor VII.Tse nkiloeng li tloaelehile ho lefu la sebete, DIC, li-anti-factor VII antibodies ho potoloha ha mali le li-anticoagulants tsa molomo.
(4) Ka bobeli APTT le PT li lelefalitsoe: mathata a mangata a ho tsoa mali a bakoang ke bokooa tseleng e tloaelehileng ea coagulation, e kang ho haella ha liphatsa tsa lefutso le tse fumanoeng X, V, II le I.Tse nkiloeng li bonoa haholo ka lefu la sebete le DIC, 'me lintlha tsa X le II li ka fokotsoa ha ho sebelisoa li-anticoagulants tsa molomo.Ho phaella moo, ha ho na le li-anti-factor X, anti-factor V le anti-factor II li-antibodies ho potoloha ha mali, li boetse li lelefalitsoe ka tsela e nepahetseng.Ha heparin e sebelisoa tleliniking, ka bobeli APTTT le PT li lelefatsoa ho latela.