Tlas'a maemo a fisioloji, litsamaiso tse peli tsa coagulation ea mali le anticoagulation 'meleng li boloka botsitso bo matla ho boloka mali a phalla ka har'a methapo ea mali.Haeba ho leka-lekana ho sa leka-lekane, tsamaiso ea anticoagulation e atile 'me tšekamelo ea ho tsoa mali e atisa ho etsahala,' me tsamaiso ea coagulation e atile 'me thrombosis e atisa ho etsahala.Sistimi ea fibrinolysis e bapala karolo ea bohlokoa ho thrombolysis.Kajeno re tla bua ka matšoao a mang a mabeli a tsamaiso ea fibrinolysis, D-dimer le FDP, ho utloisisa ka botlalo hemostasis e hlahisoang ke thrombin ho thrombus e qalileng ke fibrinolysis.Evolution.Fana ka lintlha tsa mantlha tsa kliniki mabapi le thrombosis ea bakuli le ts'ebetso ea coagulation.
D-dimer ke sehlahisoa se ikhethileng sa degradation se hlahisoang ke fibrin monomer cross-linked by activated factor XIII and then hydrolyzed by plasmin.D-dimer e tsoa ho lesela la fibrin le kopantsoeng le sefapano le qhibilihang ke plasmin.D-dimer e phahameng e bontša boteng ba hyperfibrinolysis ea bobeli (e kang DIC).FDP ke lentsoe le akaretsang la lihlahisoa tse senyang tse hlahisoang ka mor'a hore fibrin kapa fibrinogen e robehe tlas'a ketso ea plasmin e hlahisoang nakong ea hyperfibrinolysis.FDP e kenyelletsa lihlahisoa tsa fibrinogen (Fg) le lihlahisoa tsa fibrin monomer (FM) (FgDPs), hammoho le lihlahisoa tsa ho senyeha ha fibrin tse amanang le sefapano (FbDPs), tseo FbDPs li kenyelletsang D-dimers le likaroloana tse ling, 'me maemo a tsona a eketseha Holimo ho bontša hore ts'ebetso ea fibrinolytic ke hyperactive (fibrinolysis ea mantlha kapa fibrinolysis ea bobeli)
【Mohlala】
Monna ea lilemong tse bohareng o ile a kenngoa sepetlele 'me liphello tsa tlhahlobo ea mali e ile ea e-ba tse latelang:
| Ntho | Sephetho | Reference Range |
| PT | 13.2 | 10-14s |
| APTT | 28.7 | 22-32s |
| TT | 15.4 | 14-21s |
| FIB | 3.2 | 1.8-3.5g/l |
| DD | 40.82 | 0-0.55mg/I FEU |
| FDP | 3.8 | 0-5mg/l |
| AT-III | 112 | 75-125% |
Lintho tse 'nè tsa coagulation kaofela li ne li le mpe, D-dimer e ne e le ntle,' me FDP e ne e le mpe, 'me liphello li ne li hanyetsana.Qalong ho neng ho belaelloa hore e na le phello ea hook, sampole e ile ea hlahlobjoa hape ke tlhahlobo ea ho hlapolla ea 1:10 ea mantlha, sephetho e bile se latelang:
| Ntho | Ea mantlha | 1:10 dilution | Reference Range |
| DD | 38.45 | 11.12 | 0-0.55mg/I FEU |
| FDP | 3.4 | Ka tlase ho moeli o tlase | 0-5mg/l |
Ho ka bonoa ka ho hlapolloa hore sephetho sa FDP se lokela ho ba se tloaelehileng, 'me D-dimer ha e na moeli ka mor'a ho hlapolloa,' me ho belaelloa hore ho na le tšitiso.Se kenyeletse hemolysis, lipemia, le jaundice boemong ba sampole.Ka lebaka la liphello tse sa leka-lekaneng tsa dilution, linyeoe tse joalo li ka 'na tsa e-ba le tšitiso e tloaelehileng ea li-antibodies tsa heterophilic kapa mabaka a rheumatoid.Sheba nalane ea bongaka ea mokuli mme u fumane nalane ea ramatiki ea ramatiki.Laboratori Sephetho sa tlhahlobo ea RF factor se ne se batla se le holimo.Ka mor'a ho buisana le tleliniki, mokuli o ile a bolelloa 'me a fana ka tlaleho.Ka mor'a tlhahlobo ea morao-rao, mokuli o ne a se na matšoao a amanang le thrombus 'me a nkoa e le nyeoe e fosahetseng ea D-dimer.
【Kakaretso】
D-dimer ke sesupo sa bohlokoa sa ho behelloa ka thoko ho thrombosis.E na le kutlo e phahameng, empa sekhetho se ts'oanang se tla fokola.Hape ho na le karolo e itseng ea lintlha tse fosahetseng.Motsoako oa D-dimer le FDP o ka fokotsa karolo ea D- Bakeng sa phoso e fosahetseng ea dimer, ha sephetho sa laboratori se bontša hore D-dimer ≥ FDP, ho ka etsoa likahlolo tse latelang sephethong sa tlhahlobo:
1. Haeba litekanyetso li le tlase (
2. Haeba sephetho e le boleng bo phahameng (> Boleng ba ho khaola), hlahloba lintlha tse susumetsang, ho ka 'na ha e-ba le lintho tse sitisang.Ho kgothaletswa ho etsa tlhahlobo ea dilution tse ngata.Haeba sephetho se na le linear, ho ka etsahala hore motho a be le positi ea 'nete.Haeba e se linear, tse fosahetseng.U ka sebelisa reagent ea bobeli ho netefatsa le ho buisana le tleliniki ka nako.
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