D-dimer hangata e sebelisoa e le e 'ngoe ea matšoao a bohlokoa a belaelloang a PTE le DVT ts'ebetsong ea bongaka.E bile teng joang?

Plasma D-dimer ke sehlahisoa se ikhethileng sa degradation se hlahisoang ke plasmin hydrolysis ka mor'a hore fibrin monomer e hokahane le activating factor XIII.Ke letšoao le ikhethileng la ts'ebetso ea fibrinolysis.Li-D-dimers li tsoa ho likhoele tsa fibrin tse amanang le sefapano tse lysed ke plasmin.Ha feela ho ntse ho e-na le ts'ebetso e sebetsang ea thrombosis le fibrinolytic methapong ea mali ea 'mele, D-dimer e tla eketseha.Myocardial infarction, cerebral infarction, pulmonary embolism, venous thrombosis, opereishene, hlahala, ho phatlalatsoa ha methapo ea methapo, ts'oaetso le necrosis ea lisele li ka lebisa ho phahameng D-dimer.Haholo-holo ho bakuli ba tsofetseng le ba sepetlele, ka lebaka la baktheria le mafu a mang, ho bonolo ho etsa hore mali a kopane ka tsela e sa tloaelehang le ho lebisa ho eketseha ha D-dimer.

D-dimer haholo-holo e bonahatsa mosebetsi oa fibrinolytic.Keketseho kapa e ntle e bonoang ka hyperfibrinolysis ea bobeli, joalo ka hypercoagulable state, coagulation ea methapo, lefu la renal, ho hana ho fetisoa ha setho, kalafo ea thrombolytic, joalo-joalo. tsamaiso ea fibrinolytic (e kang DIC, thrombus e fapaneng) le mafu a amanang le tsamaiso ea fibrinolytic (e kang lihlahala, lefu la bokhachane), le ho hlahloba phekolo ea thrombolytic.

Maemo a phahameng a D-dimer, sehlahisoa sa ho senyeha ha fibrin, a bontša ho senyeha ha fibrin khafetsa ka vivo.Ka hona, fibrous D-dimer ke sesupo sa bohlokoa sa deep vein thrombosis (DVT), pulmonary embolism (PE), disseminated intravascular coagulation (DIC).

Maloetse a mangata a baka ts'ebetsong ea tsamaiso ea coagulation le / kapa tsamaiso ea fibrinolytic 'meleng, e leng se etsang hore ho be le keketseho ea boemo ba D-dimer,' me ts'ebetso ena e amana haufi-ufi le sethaleng, boima le phekolo ea lefu lena, kahoo mafung ana. Ho lemoha boemo ba D-dimer ho ka sebelisoa e le letšoao la tlhahlobo bakeng sa boemo ba mafu, boits'oaro le tataiso ea kalafo.

Tšebeliso ea D-dimer ho thrombosis e tebileng ea methapo

Ho tloha ha Wilson et al.Ka lekhetlo la pele ho sebelisoa lihlahisoa tsa ho senyeha ha fibrin bakeng sa tlhahlobo ea pulmonary embolism ka 1971, ho fumanoa ha D-dimer ho phethile karolo e kholo ho fumanoeng ha pulmonary embolism.Ka mekhoa e meng e hlokolosi haholo ea ho lemoha, boleng ba 'mele ba D-dimer bo na le phello e ntle ea ho bolela esale pele bakeng sa pulmonary embolism,' me boleng ba eona ke 0.99.Phello e mpe e ka thibela embolism ea pulmonary, kahoo ea fokotsa litlhahlobo tse hlaselang, tse kang ho hlahloba moea oa moea le pulmonary angiography;qoba phekolo ea bofofu ea anticoagulation.D - Motsoako oa dimer o amana le sebaka sa thrombus, se nang le likhahla tse phahameng makaleng a maholo a kutu ea pulmonary le likhahla tse tlaase makaleng a manyenyane.

D-dimers ea plasma e mpe e thibela monyetla oa ho ba le DVT.Angiography e netefalitse hore DVT e ne e le ntle ka 100% bakeng sa D-dimer.E ka sebelisoa bakeng sa kalafo ea thrombolytic le tataiso ea meriana ea anticoagulation ea heparin le tlhahlobo ea katleho.

D-dimer e ka bonahatsa liphetoho tsa boholo ba thrombus.Haeba litaba li eketseha hape, li bontša ho khutla ha thrombus;nakong ea phekolo, e ntse e tsoela pele ho ba holimo, 'me boholo ba thrombus ha bo fetohe, bo bontšang hore phekolo ha e sebetse.