Lithuto tse peli tsa bohlokoa tsa coagulation ea mali, activated partial thromboplastin time (APTT) le prothrombin time (PT), ka bobeli li thusa ho fumana sesosa sa ho se tloaelehe ha coagulation.
Ho boloka mali a le boemong ba mokelikeli，'Mele o tlameha ho etsa ketso e bonolo ea ho leka-lekanya.Mali a potolohang a na le likarolo tse peli tsa mali, procoagulant, e khothalletsang ho kopana ha mali, le anticoagulant, e thibelang ho kopana, ho boloka phallo ea mali.Leha ho le joalo, ha methapo ea mali e senyehile 'me ho leka-lekana ho ferekanngoa, procoagulant e bokella sebakeng se senyehileng' me ho qala ho koala mali.Ts'ebetso ea coagulation ea mali ke sehokelo-ka-link, 'me e ka sebelisoa ke mekhoa efe kapa efe e' meli ea coagulation ka tsela e tšoanang, e ka hare kapa ea kantle.Endogenous system e sebetsa ha mali a kopana le collagen kapa endothelium e senyehileng.Sistimi ea kantle e sebetsa ha lisele tse senyehileng li ntša lintho tse itseng tsa coagulation joalo ka thromboplastin.Tsela ea ho qetela e tloaelehileng ea litsamaiso tse peli tse lebisang tlhōrōng ea condensation.Ha ts'ebetso ena ea coagulation, le hoja e bonahala e le hang-hang, ho ka etsoa liteko tse peli tsa bohlokoa tsa ho hlahloba, nako ea karolo ea thromboplastin (APTT) le prothrombin time (PT).Ho etsa liteko tsena ho thusa ho etsa tlhahlobo e kholo ea lintho tse sa tloaelehang tsa coagulation.

 

1. APTT e bontša eng?

Teko ea APTT e lekola mekhoa e sa feleng le e tloaelehileng ea coagulation.Ka ho khetheha, e lekanya hore na ho nka nako e kae hore sampuli ea mali e etse lesela la fibrin ka ho eketsoa ha ntho e sebetsang (calcium) le phospholipids.E bonolo ebile e potlakile ho feta nako ea karolo ea thromboplastin.Hangata APTT e sebelisoa ho lekola kalafo ka sebete sa violet.

Laeborari e 'ngoe le e' ngoe e na le boleng ba eona bo tloaelehileng ba APTT, empa ka kakaretso e tloha ho metsotsoana e 16 ho isa ho e 40.Nako e telele e ka 'na ea bontša ho se lekane ha sebaka sa bone sa tsela ea endogenous, Xia kapa factor, kapa ntho e haellang ea I, V kapa X ea tsela e tloaelehileng.Bakuli ba nang le khaello ea vithamine K, lefu la sebete, kapa intravascular coagulopathy e phatlalalitsoeng ba tla lelefatsa APTT.Lithethefatsi tse ling—lithibela-mafu, li-anticoagulant, lithethefatsi, lithethefatsi, kapa aspirin le tsona li ka lelefatsa APTT.

Ho fokotseha ha APTT ho ka bakoa ke ho tsoa mali haholo, liso tse tebileng (ntle le mofetše oa sebete) le liphekolo tse ling tsa lithethefatsi tse kenyelletsang li-antihistamine, li-antacids, litokisetso tsa digitalis, joalo-joalo.

2. PT e bontša eng?

Teko ea PT e lekola litsela tsa kantle le tse tloaelehileng tsa ho koala.Bakeng sa ho lekola kalafo ka li-anticoagulants.Teko ena e lekanya nako eo plasma e e nkang hore e koale ka mor'a ho eketsoa ha ntho ea 'mele le calcium sampoleng ea mali.Mofuta o tloaelehileng oa PT ke metsotsoana e 11 ho isa ho e 16.Ho eketsa nako ea PT ho ka bontša khaello ea thrombin profibrinogen kapa factor V, W kapa X.

Bakuli ba nang le ho hlatsa, letšollo, ho ja meroho e makhasi a matala, joala kapa phekolo ea nako e telele ea lithibela-mafu, lithethefatsi tse thibelang khatello ea kelello, li-anticoagulants tsa molomo, lithethefatsi le litekanyetso tse ngata tsa aspirin le bona ba ka lelefatsa PT.PT ea boemo bo tlaase e ka boela ea bakoa ke li-barbiturates tsa antihistamine, li-antacids, kapa vithamine K.

Haeba PT ea mokuli e feta metsotsoana e 40, ho tla hlokahala vithamine K kapa plasma e hatselitsoeng e sa tsoa omisoa.Lekola mali a mokuli nako le nako, hlahloba boemo ba methapo ea hae, 'me u etse liteko tsa mali tse amanang le boloi morotong le mantleng.

 

3. Hlalosa liphello

Mokuli ea nang le coagulation e sa tloaelehang hangata o hloka liteko tse peli, APTT le PT, 'me o tla hloka hore u hlalose liphetho tsena, u fetise liteko tsa nako,' me qetellong u hlophise phekolo ea hae.