Bafuputsi Univesithing ea Monash ba thehile antibody e ncha e ka thibelang protheine e itseng maling ho thibela thrombosis ntle le litla-morao tse ka bang teng.Antibody ena e ka thibela pathological thrombosis, e ka bakang tlhaselo ea pelo le stroke ntle le ho ama ts'ebetso e tloaelehileng ea ho koala mali.

Ho hlaseloa ke pelo le stroke e ntse e le tsona lisosa tse ka sehloohong tsa lefu le mafu lefatšeng ka bophara.Litlhare tsa morao-rao tsa antithrombotic (anticoagulant) li ka baka mathata a tebileng a ho tsoa mali hobane li boetse li kena-kenana le ho hoama ho tloaelehileng ha mali.Karolo ea bone ho ba bohlano ea bakuli ba fumanang kalafo ea antiplatelet ba ntse ba e-na le liketsahalo tsa pelo tse etsahalang khafetsa.

Ka hona, lithethefatsi tse teng tsa antiplatelet li ke ke tsa sebelisoa ka tekanyo e kholo.Ka hona, katleho ea kliniki e ntse e soetseha, 'me liphekolo tsa nakong e tlang li hloka ho hlophisoa bocha.

Mokhoa oa ho etsa lipatlisiso ke oa ho qala ka ho fumana phapang ea baeloji pakeng tsa coagulation e tloaelehileng le pathological coagulation, le ho fumana hore von Willebrand factor (VWF) e fetola thepa ea eona ha thrombus e kotsi e thehoa.Boithuto bona bo entse sethibela-mafu se lemohang feela le ho thibela mofuta ona oa lefu la VWF, hobane o sebetsa feela ha leqeba la mali le fetoha lefu.

Boithuto bo ile ba sekaseka litšoaneleho tsa li-anti-VWF tse teng 'me tsa fumana litšoaneleho tse ntle ka ho fetisisa tsa anti-VWF ka 'ngoe ho tlama le ho thibela VWF tlasa maemo a pathological coagulation.Ha ho se na maikutlo a mabe, lisireletsi tsena tse ka bang teng li qala ho kopanngoa ho ba sebopeho se secha sa mali ho thibela mathata ana a ka bang teng.

Baoki ha joale ba tobane le ho leka-lekana pakeng tsa matla a lithethefatsi le litla-morao tse tsoang mali.Sethibela-mafu se entsoeng ka boenjiniere se entsoe ka mokhoa o khethehileng 'me se ke ke sa kena-kenana le ho kopana ha mali ho tloaelehileng, kahoo ho tšeptjoa hore se ka sebelisa tekanyo e phahameng le e sebetsang ho feta mekhoa ea phekolo e teng.

Thuto ena ea in vitro e entsoe ka lisampole tsa mali a motho.Mohato o latelang ke ho leka ho sebetsa hantle ha lesole la 'mele mofuteng oa phoofolo e nyane ho utloisisa hore na le sebetsa joang tsamaisong e rarahaneng ea bophelo e ts'oanang le ea rona.

Tlhaloso: Thomas Hoefer et al.Targeting shear gradient e kentsoeng tšebetsong ea von Willebrand factor ke buka e ncha ea anti-chain A1 e fokotsa sebopeho sa occlusive thrombus in vitro, Haematologica (2020).