01.Tlhaloso ea thrombosis ea methapo e tebileng le embolism ea pulmonary

Deep vein thrombosis (D-VT) e atisa ho ba pulmonary embolism (PE), e tsejoang ka kakaretso e le venous thromboembolism (VTE).Maemo a Plasma D-dimer a phahame haholo ho bakuli ba VTE.

Liphuputso tse amanang le tsona li bontšitse hore khatello ea plasma D-dimer ho bakuli ba nang le PE le D-VT e kholo ho feta 1 000 μg/L.

Leha ho le joalo, ka lebaka la maloetse a mangata kapa lintho tse ling tsa pathological (opereishene, lihlahala, mafu a pelo, joalo-joalo) li na le tšusumetso e itseng ho hemostasis, e leng se fellang ka ho eketseha ha D-dimer.Ka hona, le hoja D-dimer e na le kutlo e phahameng, ho khetheha ha eona ke 50% ho 70% feela, 'me D-dimer feela e ke ke ea hlahloba VTE.Ka hona, keketseho e kholo ea D-dimer e ke ke ea sebelisoa e le pontšo e itseng ea VTE.Bohlokoa bo sebetsang ba tlhahlobo ea D-dimer ke hore sephetho se fosahetseng se thibela ho fumanoa ha VTE.

 

02 Ho phatlalatsoa ha intravascular coagulation

Dissemination intravascular coagulation (DIC) ke lefu la microthrombosis e pharaletseng lijaneng tse nyane ho pholletsa le 'mele le hyperfibrinolysis ea bobeli tlas'a ketso ea lintlha tse itseng tsa pathogenic, tse ka tsamaeang le fibrinolysis ea bobeli kapa fibrinolysis e thibetsoeng.

Tekanyo e phahameng ea plasma ea D-dimer e na le boleng bo phahameng ba kliniki bakeng sa tlhahlobo ea pele ea DIC.Leha ho le joalo, hoa lokela ho hlokomeloa hore ho eketseha ha D-dimer hase teko e khethehileng bakeng sa DIC, empa maloetse a mangata a tsamaeang le microthrombosis a ka lebisa ho eketseha ha D-dimer.Ha fibrinolysis e le ea bobeli ho extravascular coagulation, D-dimer le eona e tla eketseha.

Liphuputso li bontšitse hore D-dimer e qala ho phahama matsatsi pele ho DIC 'me e phahame haholo ho feta e tloaelehileng.

 

03 Ho tsieleha ha lesea la Neonatal

Ho na le likhato tse fapaneng tsa hypoxia le acidosis ho neonatal asphyxia, 'me hypoxia le acidosis li ka baka tšenyo e kholo ea vascular endothelial, e leng se fellang ka ho lokolloa ha lintho tse ngata tsa coagulation, kahoo ho eketsa tlhahiso ea fibrinogen.

Liphuputso tse amehang li bontšitse hore boleng ba D-dimer ba mali a khoele sehlopheng sa asphyxia bo phahame haholo ho feta sehlopha se tloaelehileng sa taolo, 'me ha se bapisoa le boleng ba D-dimer maling a peripheral, e boetse e phahame haholo.

 

04 Systemic lupus erythematosus (SLE)

Sistimi ea coagulation-fibrinolysis e sa tloaeleha ho bakuli ba SLE, 'me ho se tloaelehe ha tsamaiso ea coagulation-fibrinolysis ho bonahala haholo sethaleng se sebetsang sa lefu lena,' me tšekamelo ea thrombosis e totobetse haholoanyane;ha lefu lena le imolohile, tsamaiso ea coagulation-fibrinolysis e atisa ho ba e tloaelehileng.

Ka hona, maemo a D-dimer a bakuli ba nang le systemic lupus erythematosus ka mekhahlelo e sebetsang le e sa sebetseng e tla eketseha haholo, 'me maemo a plasma a D-dimer a bakuli ba boemong bo sebetsang a phahame haholo ho feta ba boemong bo sa sebetseng.

05 Ho thatafala ha sebete le mofetše oa sebete

D-dimer ke e 'ngoe ea matšoao a bontšang ho teba ha lefu la sebete.Ha lefu la sebete le le matla le ho feta, ho na le boemo bo phahameng ba plasma D-dimer.

Liphuputso tse amehang li bontšitse hore boleng ba D-dimer ba limaraka tsa Ngoana-Pugh A, B, le C ho bakuli ba nang le lefu la sebete sa sebete e ne e le (2.218 ± 0.54) μg/mL, (6.03 ± 0.76) μg/mL, le (10.536 ± 0.664) μg/mL, ka ho latellana..

Ho phaella moo, D-dimer e ne e phahame haholo ho bakuli ba nang le kankere ea sebete ba nang le tsoelo-pele e potlakileng le bofokoli bo bobe.

06 Kankere ea mala

Kamora ho ts'oaroa ha bakuli ba mofets'e, thromboembolism e hlaha hoo e ka bang halofo ea bakuli, 'me D-dimer e eketseha haholo ho 90% ea bakuli.

Ho feta moo, ho na le sehlopha sa lintho tse nang le tsoekere e ngata liseleng tsa tumor tseo sebopeho sa tsona le lintlha tsa lisele li tšoanang haholo.Ho kenya letsoho mesebetsing ea metabolic ea batho ho ka khothaletsa ts'ebetso ea "coagulation system" ea 'mele le ho eketsa kotsi ea thrombosis, mme boemo ba D-dimer bo eketseha haholo.'Me boemo ba D-dimer ho bakuli ba kankere ea mala ba nang le sethaleng sa III-IV bo ne bo phahame haholo ho feta ba bakuli ba kankere ea mala ba nang le sethaleng sa I-II.

 

07 Mycoplasma pneumonia (MMP)

MPP e matla hangata e tsamaea le maemo a phahameng a D-dimer, 'me maemo a D-dimer a phahame haholo ho bakuli ba nang le MPP e matla ho feta maemong a bobebe.

Ha MPP e kula haholo, hypoxia, ischemia le acidosis li tla etsahala sebakeng sa heno, hammoho le tlhaselo e tobileng ea likokoana-hloko, tse tla senya lisele tsa vascular endothelial, li pepese collagen, li sebetse tsamaiso ea coagulation, li thehe boemo ba hypercoagulable, 'me li thehe microthrombi.Sistimi ea ka hare ea fibrinolytic, kinin le complement le eona e sebelisoa ka tatellano, e bakang ho eketseha ha maemo a D-dimer.

 

08 Lefu la tsoekere, lefu la tsoekere la nephropathy

Maemo a D-dimer a ne a phahame haholo ho bakuli ba nang le lefu la tsoekere le lefu la tsoekere la nephropathy.

Ntle le moo, li-index tsa D-dimer le fibrinogen tsa bakuli ba nang le lefu la tsoekere la nephropathy li ne li phahame haholo ho feta tsa bakuli ba lefu la tsoekere la mofuta oa 2.Ka hona, ts'ebetsong ea bongaka, D-dimer e ka sebelisoa e le index ea liteko bakeng sa ho lemoha ho teba ha lefu la tsoekere le lefu la liphio ho bakuli.

09 Allergic Purpura (AP)

Mokhahlelong o hlobaetsang oa AP, ho na le likhato tse fapaneng tsa hypercoagulability ea mali le ts'ebetso e ntlafalitsoeng ea platelet, e lebisang ho vasospasm, platelet aggregation le thrombosis.

D-dimer e phahameng ho bana ba nang le AP e tloaelehile ka mor'a libeke tse 2 tsa ho qala 'me e fapana pakeng tsa mekhahlelo ea bongaka, e bontšang boholo le tekanyo ea ho ruruha ha methapo ea methapo.

Ho phaella moo, e boetse e le pontšo ea prognostic, e nang le maemo a phahameng a sa khaotseng a D-dimer, lefu lena le atisa ho ba nako e telele 'me le atisa ho senyeha ha renal.

 

10 Boimana

Liphuputso tse amanang le tsona li bontšitse hore hoo e ka bang karolo ea 10 lekholong ea bakhachane e phahamisitse maemo a D-dimer haholo, a fana ka maikutlo a kotsi ea ho thibela mali.

Preeclampsia ke bothata bo tloaelehileng ba ho ima.Liphetoho tse kholo tsa lefu la preeclampsia le eclampsia ke ts'ebetso ea coagulation le ntlafatso ea fibrinolysis, e bakang keketseho ea microvascular thrombosis le D-dimer.

D-dimer e fokotsehile ka potlako ka mor'a ho pepa ho basali ba tloaelehileng, empa e ile ea eketseha ho basali ba nang le preeclampsia, 'me ha ea ka ea khutlela ho tloaelehileng ho fihlela libeke tse 4 ho isa ho tse 6.

11 Acute Coronary Syndrome le Dissecting Aneurysm

Bakuli ba nang le acute coronary syndromes ba na le maemo a tloaelehileng a D-dimer a tloaelehileng kapa a fokolang feela, athe aortic dissecting aneurysms e phahame haholo.

Sena se amana le phapang e kholo ea mojaro oa thrombus methapong ea methapo ea bobeli.The coronary lumen e tšesaane 'me thrombus e ka har'a methapo ea mali ea fokotseha.Ka mor'a ho phatloha ha aortic intima, mali a mangata a mangata a kena leboteng la sekepe ho theha aneurysm e senyang.Palo e kholo ea thrombi e thehoa tlas'a ketso ea mochine oa coagulation.

12 Infarction e matla ea cerebral

Ho infarction e matla ea boko, thrombolysis e ikemetseng le ts'ebetso ea bobeli ea fibrinolytic lia eketseha, e bonts'ang ka ho eketseha ha maemo a D-dimer ho plasma.Boemo ba D-dimer bo ile ba eketseha haholo mohatong oa pele oa infarction e matla ea cerebral.

Litekanyetso tsa Plasma D-dimer ho bakuli ba nang le lefu le matla la ischemic li ile tsa eketseha hanyenyane bekeng ea pele ka mor'a hore li qale, li eketsehile haholo ho 2 ho libeke tsa 4, 'me li ne li sa fapane le maemo a tloaelehileng nakong ea ho hlaphoheloa (> likhoeli tsa 3).