Bophelong, batho ba tla qhoma le ho tsoa mali nako le nako.Maemong a tloaelehileng, haeba maqeba a mang a sa phekoloe, butle-butle mali a tla hoama, a khaotse ho tsoa mali ka booona, ’me qetellong a tlohe maling.Hobaneng ho le joalo?Ke lintho life tse phethileng karolo ea bohlokoa tšebetsong ee?Ka mor'a moo, a re ke re hlahlobeng tsebo ea mali coagulation hammoho!

Joalokaha bohle re tseba, mali a lula a potoloha 'meleng oa motho tlas'a khatello ea pelo ho tsamaisa oksijene, protheine, metsi, electrolyte le lik'habohaedreite tse hlokoang ke' mele.Tlas'a maemo a tloaelehileng, mali a phalla methapong ea mali.Ha methapo ea mali e senyeha, 'mele o tla emisa ho tsoa mali le ho koala ka letoto la liketso.Coagulation e tloaelehileng le hemostasis ea 'mele oa motho e ipapisitse le sebopeho le ts'ebetso ea lebota la methapo ea mali e sa fetoheng, ts'ebetso e tloaelehileng ea lintlha tsa coagulation, le boleng le bongata ba liplatelete tse sebetsang hantle.

Tlas'a maemo a tloaelehileng, liplatelete li hlophisoa haufi le marako a ka hare a li-capillaries ho boloka botšepehi ba marako a methapo ea mali.Ha methapo ea mali e senyehile, ho fokotseha ho etsahala pele, ho etsa hore marako a methapo ea mali karolong e senyehileng e be haufi le e mong, ho fokotsa leqeba le ho fokotsa ho phalla ha mali.Ka nako e ts'oanang, liplatelete li khomarela, li kopanya le ho lokolla likahare karolong e senyehileng, ho etsa thrombus ea platelet ea sebakeng seo, ho thibela leqeba.Hemostasis ea methapo ea mali le liplatelete e bitsoa hemostasis ea pele, 'me mokhoa oa ho etsa lesela la fibrin sebakeng se lemetseng ka mor'a ho kenya tšebetsong mokhoa oa ho kopanya ho thibela leqeba ho bitsoa "secondary hemostatic mechanism".

Haholo-holo, ho kopana ha mali ho bolela mokhoa oo mali a fetohang ho tloha boemong bo phallang ho ea boemong bo sa phallang.Coagulation e bolela hore letoto la lintlha tsa coagulation li kenngoa ts'ebetsong ka ho latellana ke enzymolysis, 'me qetellong thrombin e thehoa ho theha lesela la fibrin.Mokhoa oa coagulation hangata o kenyelletsa mekhoa e meraro, endogenous coagulation pathway, exogenous coagulation pathway le common coagulation pathway.

1) Tsela ea endogenous coagulation e qalisoa ke coagulation factor XII ka karabelo ea ho kopana.Ka ts'ebetso le karabelo ea lintlha tse fapaneng tsa coagulation, prothrombin e qetella e fetoloa thrombin.Thrombin e fetolela fibrinogen ho fibrin ho fihlela sepheo sa ho kopanya mali.

2) Tsela ea exogenous coagulation e bolela ho lokolloa ha ntho ea eona ea lisele, e hlokang nako e khutšoanyane bakeng sa ho kopanya le ho arabela ka potlako.

Liphuputso li bonts'itse hore endogenous coagulation pathway le exogenous coagulation pathway e ka kengoa ts'ebetsong 'me ea sebelisoa ka bobeli.

3) Tsela e tloaelehileng ea coagulation e bua ka mohato o tloaelehileng oa coagulation ea endogenous coagulation system le exogenous coagulation system, eo haholo-holo e kenyelletsang mekhahlelo e 'meli ea moloko oa thrombin le ho thehoa ha fibrin.

Ho thoeng ke hemostasis le tšenyo ea methapo ea mali, e etsang hore ho be le exogenous coagulation tsela.Mosebetsi oa fisioloji oa endogenous coagulation pathway hajoale ha o hlake hantle.Leha ho le joalo, ho na le bonnete ba hore tsela ea "endogenous blood coagulation" e ka etsoa ha 'mele oa motho o kopana le lisebelisoa tsa maiketsetso, e leng se bolelang hore lisebelisoa tsa likokoana-hloko li ka baka ho kopana ha mali' meleng oa motho, 'me ketsahalo ena e boetse e fetohile tšitiso e kholo ho batho. ho kenngoa ha lisebelisoa tsa bongaka 'meleng oa motho.

Lintho tse sa tloaelehang kapa litšitiso ho ntho efe kapa efe ea coagulation kapa sehokelo sa coagulation se tla baka ho se tloaelehe kapa ho se sebetse hantle ts'ebetsong eohle ea coagulation.Hoa hlokomeleha hore ho kopana ha mali ke mokhoa o rarahaneng le o bonolo 'meleng oa motho, o phethang karolo ea bohlokoa ho boloka bophelo ba rona.