(1) D-dimer
Joalo ka sehlahisoa se senyehileng sa fibrin e hokahaneng, D-dimer ke sesupo se tloaelehileng se bonts'ang ts'ebetso ea coagulation le hyperfibrinolysis ea bobeli.Ho bakuli ba nang le COVID-19, maemo a phahameng a D-dimer ke letšoao la bohlokoa bakeng sa mathata a ka bang teng a coagulation.Maemo a D-dimer le ona a amana haufi-ufi le ho teba ha mafu, 'me bakuli ba nang le D-dimer e phahameng haholo ha ba kenoa ba na le ponelopele e mpe le ho feta.Litaelo tse tsoang ho Mokhatlo oa Machaba oa Thrombosis le Hemostasis (ISTH) li khothaletsa hore D-dimer e phahameng haholo (ka kakaretso e fetang makhetlo a 3 kapa a 4 moeling o kaholimo ho tloaelehileng) e ka ba sesupo sa ho kena sepetlele ho bakuli ba COVID-19, kamora ho qheleloa ka thoko ho li-contraindication. Anticoagulation e nang le litekanyetso tsa prophylactic tsa heparin ea boima bo tlase ba limolek'hule e lokela ho fuoa bakuli ba joalo kapele kamoo ho ka khonehang.Ha D-dimer e ntse e phahama butle butle mme ho na le lipelaelo tse ngata tsa venous thrombosis kapa microvascular embolism, anticoagulation e nang le litekanyetso tsa kalafo ea heparin e lokela ho nahanoa.

Leha D-dimer e phahameng e ka boela ea fana ka maikutlo a hyperfibrinolysis, tšekamelo ea ho tsoa mali ho bakuli ba COVID-19 ba nang le D-dimer e phahameng haholo ha e ea tloaeleha ntle le haeba e hatela pele ho karolo e hlakileng ea DIC hypocoagulable, e fana ka maikutlo a hore COVID-19 Sistimi ea fibrinolytic ea -19 e ntse e thibetsoe haholo.Lesupa le leng le amanang le fibrin, ke hore, phetoho ea boemo ba FDP le boemo ba D-dimer e ne e tšoana hantle.

 

(2) PT
Nako e telele ea PT hape ke sesupo sa mathata a ka bang teng a coagulation ho bakuli ba COVID-19 mme ho bonts'itsoe hore e amahanngoa le ponelopele e mpe.Boemong ba pele ba lefu la coagulation ho COVID-19, bakuli ba nang le PT hangata ba tloaelehile kapa ba fokola hanyane, mme PT e telele nakong ea hypercoagulable hangata e bonts'a ts'ebetso le ts'ebeliso ea lintlha tse kantle tsa coagulation, hammoho le ho fokotseha ha fibrin polymerization, kahoo e boetse e le anticoagulation e thibelang.e 'ngoe ea lipontšo.Leha ho le joalo, ha PT e ntse e tsoela pele nako e telele haholo, haholo-holo ha mokuli a e-na le lipontšo tsa mali, e bontša hore lefu la coagulation le kene boemong bo tlaase ba coagulation, kapa mokuli o rarahane ke ho se sebetse ha sebete, ho haelloa ke vithamine K, ho feta tekano ea anticoagulant, joalo-joalo, Ho lokela ho nahanoa ka tšelo ea plasma.Phekolo e 'ngoe.Ntho e 'ngoe ea tlhahlobo ea coagulation, e kentsoeng partial thromboplastin time (APTT), e lula e le maemong a tloaelehileng nakong ea hypercoagulable phase of coagulation disorders, e ka hlahisoang ke ho eketseha ha tšebetso ea factor VIII maemong a ho ruruha.

 

(3) Palo ea liplatelete le tlhahlobo ea ts'ebetso
Le ha ts'ebetso ea coagulation e ka lebisa ho fokotseheng ha tšebeliso ea liplatelete, lipalo tse fokotsehileng tsa liplatelete ha li tloaelehe ho bakuli ba COVID-19, e kanna ea amana le ho eketseha ha tokollo ea thrombopoietin, IL-6, li-cytokines tse khothalletsang ts'ebetso ea platelet libakeng tsa ho ruruha Ka hona, boleng bo felletseng ba palo ea liplatelete ha se sesupo se hlokolosi se bonts'ang mathata a coagulation ho COVID-19, 'me ho ka ba bohlokoa haholo ho ela hloko liphetoho tsa eona.Ho feta moo, ho fokotseha ha palo ea liplatelete ho amahanngoa haholo le bofokoli bo bobe hape ke e 'ngoe ea matšoao a prophylactic anticoagulation.Leha ho le joalo, ha palo e fokotsehile haholo (mohlala, <50 × 109 / L), 'me mokuli a e-na le lipontšo tsa mali, tšelo ea karolo ea platelet e lokela ho nkoa.

Joalo ka sephetho sa lithuto tse fetileng ho bakuli ba nang le sepsis, liteko tsa in vitro platelet function ho bakuli ba COVID-19 ba nang le mathata a coagulation hangata li fana ka liphetho tse tlase, empa liplatelete tsa 'nete ho bakuli hangata lia kengoa, tse ka bakoang ke ts'ebetso e tlase.Li-platelet tse phahameng li sebelisoa pele 'me li jeoa ke mokhoa oa ho kopanya,' me mosebetsi o lekanyelitsoeng oa li-platelet potolohong e bokelitsoeng e tlaase.

 

(4) FIB
Joalo ka protheine ea karabelo e matla, bakuli ba nang le COVID-19 hangata ba na le maemo a phahameng a FIB maemong a hlobaetsang a ts'oaetso, e sa amaneng feela le ho teba ha ho ruruha, empa FIB e phahameng ka boeona le eona e baka kotsi ea thrombosis. e ka sebelisoa joalo ka COVID-19 E 'ngoe ea matšoao a anticoagulation ho bakuli.Leha ho le joalo, ha mokuli a e-na le ho fokotseha ho tsoelang pele ho FIB, ho ka 'na ha bontša hore lefu la coagulation le tsoetse pele ho fihlela boemong ba hypocoagulable, kapa mokuli o na le bothata bo matla ba sebete, boo hangata bo hlahang qetellong ea lefu lena, ha FIB<1.5 g /L le ho tsamaea le ho tsoa mali , infusion ea FIB e lokela ho nkoa.