'Mele o tloaelehileng o na le tsamaiso e feletseng ea coagulation le anticoagulation.The coagulation system le anticoagulation system li boloka botsitso bo matla ho netefatsa hore 'mele o na le hemostasis le phallo ea mali e boreleli.Hang ha ts'ebetso ea coagulation le anticoagulation e ferekanngoa, e tla lebisa ho tsoa mali le tšekamelo ea thrombosis.

1. Ts'ebetso ea 'mele ea coagulation

The coagulation system haholo-holo e entsoe ka mabaka a coagulation.Lintho tse amehang ka ho toba ho coagulation li bitsoa coagulation factor.Ho na le lintlha tse 13 tse tsebahalang tsa coagulation.

Ho na le litsela tsa ts'ebetso ea endogenous le litsela tsa ts'ebetso ea exogenous bakeng sa ts'ebetso ea lintlha tsa coagulation.

Hona joale ho lumeloa hore ts'ebetso ea "exogenous coagulation system" e qalisoang ke "tissue factor" e phetha karolo e kholo ho qaleng ha coagulation.Kamano e haufi pakeng tsa tsamaiso ea ka hare le ea ka ntle ea coagulation e phetha karolo ea bohlokoa ho qalisa le ho boloka mokhoa oa ho kopanya.

2. Mosebetsi oa 'mele oa anticoagulant

Sistimi ea anticoagulation e kenyelletsa sistimi ea cellular anticoagulation le sistimi ea anticoagulation ea 'mele.

①Sistimi ea anticoagulation ea lisele

E bua ka phagocytosis ea coagulation factor, factor factor, prothrombin complex le soluble fibrin monomer ke tsamaiso ea mononuclear-phagocyte.

②Sistimi ea anticoagulation ea 'mele

Ho kenyeletsa: serine protease inhibitors, protein C-based protease inhibitors le tissue factor pathway inhibitors (TFPI).

3. Sistimi ea Fibrinolytic le mesebetsi ea eona

Haholo-holo e kenyeletsa plasminogen, plasmin, plasminogen activator le fibrinolysis inhibitor.

Karolo ea tsamaiso ea fibrinolytic: qhala maqeba a fibrin le ho netefatsa phallo ea mali e boreleli;kenya letsoho tokisong ea lisele le ho nchafatsa methapo ea mali.

4. Karolo ea lisele tsa vascular endothelial ts'ebetsong ea coagulation, anticoagulation le fibrinolysis.

① Hlahisa lintho tse fapaneng tse sebetsang ka baeloji;

②Laola ho kopanya mali le mosebetsi oa anticoagulation;

③ Fetola mosebetsi oa tsamaiso ea fibrinolysis;

④ Laola tsitsipano ea methapo ea mali;

⑤Ho kenya letsoho lipuisanong tsa ho ruruha;

⑥Ho boloka tšebetso ea microcirculation, joalo-joalo.

Coagulation le mathata a anticoagulant

1. Lintho tse sa tloaelehang ho coagulation factor.

2. Ho se tloaelehe ha lintlha tsa anticoagulant ka plasma.

3. Ho se tloaelehe ha ntlha ea fibrinolytic ka plasma.

4. Ho se tloaelehe ha lisele tsa mali.

5. Methapo e sa tloaelehang ea mali.