D-dimer waxaa badanaa loo isticmaalaa mid ka mid ah tilmaamayaasha muhiimka ah ee looga shakisan yahay PTE iyo DVT ee ku saabsan waxqabadka bukaan-socodka.Sidee ku timid?

Plasma D-dimer waa wax soo saar gaar ah oo hoos u dhac ah oo ay soo saarto plasmin hydrolysis ka dib markii fibrin monomer uu isku xidho iyada oo la dhaqaajinayo factor XIII.Waa calaamad gaar ah oo habka fibrinolysis.D-dimers waxay ka soo jeedaan xinjiraha fibrin ee isku-tallaaban ee lysed by plasmin.Ilaa iyo inta uu jiro xinjirowga firfircoon ee xinjirowga dhiigga iyo dhaqdhaqaaqa fibrinolytic ee xididdada dhiigga ee jirka, D-dimer wuu kordhi doonaa.Wadnaha wadnaha, wadnaxanuun maskaxda, sambabada sambabada, xinjirowga xididka, qaliinka, buro, faafinta xinjirowga xididdada dhiigga, caabuqa iyo necrosis unug waxay keeni kartaa kor u D-dimer.Gaar ahaan dadka da'da ah iyo bukaannada isbitaallada, bakteeriyadu iyo cudurrada kale awgeed, way sahlan tahay in ay keento xinjirowga dhiigga oo aan caadi ahayn oo keena kororka D-dimer.

D-dimer waxay inta badan ka tarjumaysaa shaqada fibrinolytic.Kordhinta ama togan ee lagu arkay hyperfibrinolysis labaad, sida gobolka hypercoagulable, faafin xinjirowga xididada, cudurada kelyaha, diidmada xubinta taranka, therapy thrombolytic, iwm. nidaamka fibrinolytic (sida DIC, thrombus kala duwan) iyo cudurada la xiriira nidaamka fibrinolytic (sida burooyinka, uurka syndrome), iyo la socodka daaweynta thrombolytic.

Heerarka sare ee D-dimer, wax soo saarka naafaynta fibrin, ayaa muujinaya hoos u dhac joogta ah oo fibrin ah gudaha vivo.Sidaa darteed, D-dimer fibre waa tilmaame fure u ah xinjirowga dhiigga ee qoto dheer (DVT), sambabada sambabada (PE), xinjirowga dhiigga ee la faafiyay (DIC).

Cudurro badan ayaa keena firfircoonida nidaamka xinjirowga iyo / ama nidaamka fibrinolytic ee jirka, taasoo keentay kororka heerka D-dimer, firfircoonidani waxay si dhow ula xiriirtaa marxaladda, darnaanta iyo daaweynta cudurka, sidaas darteed cuduradan Ogaanshaha heerka D-dimer waxa loo isticmaali karaa calaamad qiimayneed oo loogu talagalay habaynta cudurka, saadaasha iyo hagida daawaynta.

Codsiga D-dimer ee xididdada qotodheer ee thrombosis

Tan iyo Wilson et al.Markii ugu horreysay ee la codsado alaabada hoos u dhigaysa fibrin si loo ogaado cudurka sambabada sambabada 1971, ogaanshaha D-dimer ayaa door weyn ka ciyaartay ogaanshaha sambabada sambabada.Qaar ka mid ah hababka ogaanshaha aadka u xasaasiga ah, D-dimer Qiimaha Jirka xun wuxuu leeyahay saameyn xun oo saadaalin ah oo sambabada sambabada, qiimihiisuna waa 0.99.Natiijo taban ayaa asal ahaan meesha ka saari karta sambabada sambabada, taaso hoos u dhigaysa baadhista caabuqa, sida iskaanka dhiiga hawada iyo angiography sambabada;ka fogow daaweynta xinjirowga lidka ku ah indho-la'aanta.D - Dimer-ku-ururinta waxay la xiriirtaa meesha uu ku yaal xinjirowga dhiigga, oo leh xaddi sare oo ka mid ah laamaha waaweyn ee jirridda sambabada iyo hoos u dhigista laamaha yaryar.

D-dimers balaasmaha xun ayaa meesha ka saaraya suurtagalnimada DVT.Angiography ayaa xaqiijiyay in DVT ay 100% togan u tahay D-dimer.Waxa loo isticmaali karaa daawaynta thrombolytic iyo hagida daawada xinjirowga lidka ku ah heparin iyo la socoshada waxtarka leh.

D-dimer waxay ka tarjumaysaa isbeddelada cabbirka thrombus.Haddii maaddadu mar kale kordho, waxay muujinaysaa soo noqoshada thrombus;Inta lagu jiro muddada daaweynta, waxay sii socotaa inay sare u kacdo, xajmiga xinjirowga ma beddelo, taas oo muujinaysa in daaweyntu aysan waxtar lahayn.