01. Kutanga kuzivana neD-dimer, FDP

1. FDP ndiyo izwi rinoshandiswa kune zvakasiyana-siyana zvinosvibisa zvigadzirwa zvefibrin uye fibrinogen pasi pekuita kweplasmin, iyo inonyanya kuratidza huwandu hwefibrinolytic yemuviri;

2. D-dimer chinhu chakanyanya kukanganisa chigadzirwa chemuchinjikwa-yakabatanidzwa fibrin pasi pechiito cheplasmin, uye kuwedzera kwehuwandu hwayo kunoratidza kuvapo kwechipiri hyperfibrinolysis;

02. Clinical kushandiswa kweD-dimer uye FDP

Usasanganisa venous thrombosis (VTE inosanganisira DVT, PE)

Iko kurongeka kweD-dimer isina kunaka kusabatanidzwa kweyakadzika vein thrombosis (DVT) inogona kusvika 98% -100%

D-dimer kuona inogona kushandiswa kutonga kunze kwevenous thrombosis

♦Kukosha mukuongororwa kweDIC

1. DIC yakaoma pathophysiological process uye yakaoma yakawanikwa yekiriniki thrombo-hemorrhagic syndrome.MaDIC akawanda ane kukurumidza kutanga, chirwere chakaoma, kukura nekukurumidza, kuongororwa kwakaoma, uye kufungidzira kune ngozi.Kana zvikasaonekwa nekukurumidza uye nekurapwa zvinobudirira, Kazhinji kuisa hupenyu hwemurwere mungozi;

2. D-dimer inogona kuratidza kuoma kweDIC kune imwe nhanho, FDP inogona kushandiswa kutarisa kukura kwechirwere mushure mekunge kuongororwa kwasimbiswa, uye antithrombin (AT) inobatsira kunzwisisa kuoma kwechirwere uye kubudirira kwechirwere ichi. Heparin kurapwa Kusanganiswa kweD-dimer, FDP uye AT kuongororwa kwave chiratidzo chakanakisa chekuongorora DIC.

♦ Zvinokosha mumapundu akaipa

1. Matundu akashata anowirirana zvakanyanya nekusashanda kwehemostasis.Pasinei nemamota akasimba akasimba kana leukemia, varwere vanozove neyakakomba hypercoagulable mamiriro kana thrombosis.Adenocarcinoma yakaoma ne thrombosis ndiyo inowanzoitika;

2. Zvakakosha kusimbisa kuti thrombosis inogona kuva chiratidzo chekutanga chebundu.Muvarwere vane deep vein thrombosis inotadza kuona njodzi yekubuda ropa, panogona kuve nebundu rinogona kuitika.

♦Kukosha kwekiriniki yezvimwe zvirwere

1. Kuongororwa kwethrombolytic drug therapy

Mukati mekurapa, kana huwandu hwemishonga yethrombolytic husina kukwana uye thrombus haina kunyungudika zvachose, D-dimer uye FDP ichachengetedza yakakwirira mushure mokunge yasvika pakakwirira;nepo thrombolytic drug yakawandisa ichawedzera njodzi yekubuda ropa.

2. Kukosha kwediki molecule heparin kurapwa mushure mekuvhiyiwa

Varwere vane kushungurudzika / kuvhiyiwa vanowanzorapwa ne anticoagulant prophylaxis.

Kazhinji, muyero weiyo diki molecule heparin i2850IU/d, asi kana murwere D-dimer level iri 2ug/ml pazuva rechina mushure mekuvhiyiwa, iyo dose inogona kuwedzerwa kusvika kaviri pazuva.

3. Acute aortic dissection (AAD)

AAD ndicho chikonzero chinowanzokonzera kufa kamwe kamwe muvarwere.Kukurumidza kuongororwa uye kurapwa kunogona kuderedza huwandu hwekufa kwevarwere uye kuderedza njodzi dzekurapa.

Iyo inogoneka nzira yekuwedzera kweD-dimer muAAD: Mushure mekunge chikamu chepakati chemadziro emudziyo weaortic chakakuvadzwa nekuda kwezvikonzero zvakasiyana-siyana, rusvingo rwevascular runoputika, zvichiita kuti ropa ripinde mukati nekunze kwemukati kuumba "mhango yenhema" , nekuda kweropa rechokwadi uye renhema mumhango Pane musiyano mukuru mukumhanya kwekuyerera, uye kukurumidza kuyerera mumhango yenhema kunonoka, izvo zvinogona kukonzera thrombosis nyore, zvichiita kuti fibrinolytic system ishandiswe, uye pakupedzisira inosimudzira. kuwedzera kweD-dimer level.

03. Zvinhu zvinokanganisa D-dimer neFDP

1. Physiological maitiro

Yakakwidziridzwa: Kune misiyano yakakura muzera, vakadzi vane pamuviri, kurovedza muviri, kuenda kumwedzi.

2.Chirwere chekuita

Yakakwira: cerebrovascular stroke, thrombolytic therapy, hutachiona hwakanyanya, sepsis, tishu gangrene, preeclampsia, hypothyroidism, chirwere chechiropa chakakomba, sarcoidosis.

3.Hyperlipidemia nemigumisiro yekunwa

Yakakwirira: vanonwa;

Kuderedza: hyperlipidemia.

4. Zvinodhaka zvinokonzerwa

Yakakwirira: heparin, antihypertensive zvinodhaka, urokinase, streptokinase uye staphylokinase;

Kuderera: oral contraceptives uye estrogen.
04. Pfupiso

D-dimer uye FDP yekuona yakachengeteka, yakapfava, inokurumidza, ine mari, uye yakanyanya kunzwa.Vese vari vaviri vachange vaine madhigirii akasiyana ekuchinja kwechirwere chemoyo, chirwere chechiropa, cerebrovascular disease, nhumbu-induced hypertension, uye pre-eclampsia.Zvakakosha kutonga kuoma kwechirwere, kutarisa kukura uye kuchinja kwechirwere, uye kuongorora kufungidzira kwehutano hwekurapa.effect.