Clinical kukosha
Izvo zvine zvazvinoreva zvakafanana nenguva yekubatanidza, asi nekunzwa kwakanyanya.Mazhinji enzira dze APTT dzekutemesa dziri kushandiswa parizvino dzinogona kunge dzisina kujairika kana iyo plasma coagulation factor yakaderera pane 15% kusvika 30% yeyakajairika level.
(1) APTT kureba: mhedzisiro yeAPTT ndeye 10 masekonzi kureba kupfuura iyo yenguva dzose kutonga.APTT ndiyo yakavimbika yekuongorora bvunzo ye endogenous coagulation factor kushomeka uye inonyanya kushandiswa kutsvaga nyoro hemophilia.Kunyange zvazvo chinhu Ⅷ: C mazinga anogona kuonekwa ari pasi pe25% yehemophilia A, kunzwa kune subclinical hemophilia (factor Ⅷ> 25%) uye vatakuri vehemophilia irombo.Migumisiro yenguva refu inoonekwawo mu factor Ⅸ (hemophilia B), Ⅺ uye Ⅶ kusakwana;apo ropa anticoagulant zvinhu zvakadai se coagulation factor inhibitors kana heparin mazinga anowedzera, prothrombin, fibrinogen uye factor V, X kushayikwa zvakare Inogona kurebeswa, asi senitivity zvishoma zvishoma;Kuwedzerwa kweAPTT kunogonawo kuonekwa kune vamwe varwere vane chirwere chechiropa, DIC, uye huwandu hweropa rebhangi.
(2) APTT kupfupisa: inoonekwa muDIC, prethrombotic state uye thrombotic chirwere.
(3) Kutariswa kwekurapa kweheparin: APTT inonyanya kukoshesa kusanganiswa kweplasma heparin, saka ndiyo inoshandiswa zvakanyanya laboratory monitoring index ikozvino.Panguva ino, zvinofanirwa kucherechedzwa kuti chiyero chekuyera APTT chinofanirwa kuve nehukama hwepakati neiyo plasma yeheparin muhutano hwekurapa, zvikasadaro haifanirwe kushandiswa.Kazhinji, panguva yekurapa kweheparin, zvinokurudzirwa kuchengetedza APTT pa1.5 kusvika ku3.0 nguva yekutonga kwakajairika.
Kuongorora kwemhedzisiro
Kliniki, APTT nePT zvinowanzo shandiswa sekuongorora bvunzo dzeropa coagulation basa.Zvinoenderana nezviyero zvawanikwa, pane angangoita mana anotevera mamiriro:
(1) Zvose APTT nePT zvakajairika: Kunze kwevanhuwo zvavo, zvinongoonekwa mukushaya nhaka uye yechipiri FXIII.Anowanikwa anowanikwa muchirwere chakakomba chechiropa, bundu rechiropa, malignant lymphoma, leukemia, anti-factor XIII antibody, autoimmune anemia uye pernicious anemia.
(2) Yakareba APTT ine yakajairika PT: Mazhinji ematambudziko ekubuda ropa anokonzerwa nekukanganisa mukati memukati coagulation nzira.Zvakadai sehemophilia A, B, uye factor Ⅺ kushomeka;kune anti-factor Ⅷ, Ⅸ, Ⅺ masoja ekudzivirira chirwere mukutenderera kweropa.
(3) Yakajairika APTT ine PT yakareba: kukanganiswa kweropa kwakawanda kunokonzerwa nekukanganisa munzira yekubuda kunze, senge genetic uye yakawana factor VII inoshaya.Anowanikwa anowanikwa muchirwere chechiropa, DIC, anti-factor VII antibodies mukutenderera kweropa uye oral anticoagulants.
(4) Zvose APTT uye PT zvinorebesa: zvirwere zvakawanda zvekubuda ropa zvinokonzerwa nekukanganisa munzira yakajairika ye coagulation, yakadai se genetic uye yakawana factor X, V, II uye I kushomeka.Zvakawanikwa zvinonyanya kuonekwa muchirwere chechiropa uye DIC, uye zvinhu X uye II zvinogona kuderedzwa kana oral anticoagulants inoshandiswa.Mukuwedzera, kana pane anti-factor X, anti-factor V uye anti-factor II antibodies mukutenderera kweropa, ivo vanorebeswawo saizvozvo.Kana heparin inoshandiswa kuchipatara, zvose APTTT uye PT zvinorebeswa maererano.