Chikonzero chikuru

1. Cardiovascular endothelial kukuvara
Vascular endothelial cell kukuvadzwa ndiyo inonyanya kukosha uye inowanzokonzera thrombus kuumbwa, uye inowanzoonekwa mu rheumatic uye infective endocarditis, yakaoma atherosclerotic plaque ulcers, traumatic or inflammatory arteriovenous injury sites, etc. Kunewo hypoxia, shock, sepsis uye mabhakitiriya. endotoxins inokonzera huwandu hwakawanda hwezvirwere zvinopera mumuviri wese.
Mushure mekukuvara kweganda, iyo collagen iri pasi pe endothelium inomutsa iyo coagulation process, zvichikonzera kuparadzira intravascular coagulation, uye thrombus mafomu mu microcirculation yemuviri wese.

2. Kuyerera kweropa kusina kujairika
Zvinonyanya kureva kuderera kwekuyerera kweropa uye chizvarwa cheeddies mukuyerera kweropa, nezvimwewo, uye iyo activated coagulation factor uye thrombin inosvika pakusangana kunodiwa kuti coagulation munzvimbo yemunharaunda, iyo inobatsira pakuumbwa kwethrombus.Pakati pavo, tsinga dzinowanzoita thrombus, iyo inowanzoonekwa kune varwere vane mwoyo kusakundikana, chirwere chisingaperi uye postoperative bed rest.Mukuwedzera, ropa rinoyerera mukati memwoyo uye tsinga inokurumidza, uye hazvisi nyore kuumba thrombus.Zvisinei, kana ropa richiyerera muatrium yekuruboshwe, aneurysm, kana bazi remudziyo weropa rinononoka uye eddy ikozvino inoitika panguva yemitral valve stenosis, inowanzoita thrombosis.

3. Kuwedzera kweropa coagulation
Kazhinji, maplatelet uye coagulation zvinhu muropa zvinowedzera, kana basa re fibrinolytic system rinoderera, zvichiita kuti kuve ne hypercoagulable state muropa, iyo inowanzoonekwa munhaka uye yakawanikwa hypercoagulable states.

4. Hereditary hypercoagulable state
Iyo yakabatana nenhaka coagulation factor defects, congenital defects yeprotein C uye protein S, etc. Pakati pavo, iyo inowanzoita V gene mutation, chiyero chekuchinja kwejini iyi chinogona kusvika 60% kune varwere vane recurrent deep vein thrombosis.

5. Yakawana hypercoagulable state
Inowanzoonekwa mupancreatic cancer, kenza yemapapu, kenza yemazamu, kenza yeprostate, kenza yemudumbu uye mamwe akawanda akanyanya metastatic advanced malignant tumors, anokonzerwa nekuburitswa kweprocoagulant zvinhu nekenza masero;zvinogonawo kuitika mukushungurudzika kwakanyanya, kupisa kwakanyanya, kuvhiyiwa kukuru kana mushure mekusununguka Muchiitiko chekurasikirwa kukuru kweropa, uye mumamiriro ezvinhu akadai se gestational hypertension, hyperlipidemia, coronary atherosclerosis, kusvuta, uye kufutisa.