Pasi pemamiriro ehupenyu, maitiro maviri eropa coagulation uye anticoagulation mumuviri anochengetedza chiyero chine simba kuchengetedza ropa richiyerera mutsinga dzeropa.Kana chiyero chisina kuenzana, iyo anticoagulation system ndiyo yakanyanya uye maitiro ekubuda ropa anowanzo kuitika, uye iyo coagulation system yakanyanya uye thrombosis inowanzoitika.Iyo fibrinolysis system inoita basa rakakosha mu thrombolysis.Nhasi tichataura pamusoro pezvimwe zviratidzo zviviri zve fibrinolysis system, D-dimer uye FDP, kunyatsonzwisisa hemostasis inogadzirwa ne thrombin kune thrombus yakatangwa ne fibrinolysis.Evolution.Ipa ruzivo rwekiriniki rwekutanga nezvevarwere 'thrombosis uye coagulation basa.
D-dimer chinhu chakanyanya kushatisa chigadzirwa chinogadzirwa nefibrin monomer muchinjiko-yakabatanidzwa ne activated factor XIII uyezve hydrolyzed ne plasmin.D-dimer inotorwa kubva muchinjika-yakabatana fibrin clot yakanyungudutswa neplasmin.Yakakwirira D-dimer inoratidza kuvapo kwechipiri hyperfibrinolysis (yakadai seDIC).FDP ndiro izwi rekare rezvigadzirwa zvekuora zvinogadzirwa mushure mekunge fibrin kana fibrinogen yaputsika pasi pechiito cheplasmin chinogadzirwa panguva ye hyperfibrinolysis.FDP inosanganisira fibrinogen (Fg) uye fibrin monomer (FM) zvigadzirwa (FgDPs), pamwe neyakachinjika-yakabatana fibrin degradation zvigadzirwa (FbDPs), pakati peiyo maFbDPs anosanganisira D-dimers nezvimwe zvimedu, uye iwo mazinga anowedzera High inoratidza kuti muviri fibrinolytic basa iri hyperactive (primary fibrinolysis kana yechipiri fibrinolysis)
【Muenzaniso】
Mumwe murume wezera repakati akapinzwa muchipatara uye mhedzisiro yekuvharika kweropa yaive seizvi:
| Item | Mhedzisiro | Reference Range |
| PT | 13.2 | 10-14s |
| APTT | 28.7 | 22-32s |
| TT | 15.4 | 14-21s |
| FIB | 3.2 | 1.8-3.5g/l |
| DD | 40.82 | 0-0.55mg/I FEU |
| FDP | 3.8 | 0-5mg/l |
| AT-III | 112 | 75-125% |
Zvinhu zvina zve coagulation zvese zvaive zvisina kunaka, D-dimer yaive yakanaka, uye FDP yaive isina kunaka, uye mhedzisiro yaipokana.Pakutanga yaifungidzirwa kuve chirauro mhedzisiro, sampu yakaongororwazve neyakare yakawanda uye 1:10 dilution bvunzo, mhedzisiro yaive inotevera:
| Item | Original | 1:10 dilution | Reference Range |
| DD | 38.45 | 11.12 | 0-0.55mg/I FEU |
| FDP | 3.4 | Pasi pemuganhu wakaderera | 0-5mg/l |
Zvinogona kuonekwa kubva mukunatswa kuti mhedzisiro yeFDP inofanirwa kuve yakajairika, uye iyo D-dimer haina mutsara mushure mekuderedzwa, uye kupindira kunofungidzirwa.Usasanganise hemolysis, lipemia, uye jaundice kubva pachimiro chemuenzaniso.Nekuda kwekusaenzana kwemhedzisiro ye dilution, zviitiko zvakadaro zvinogona kuitika mukukanganisa kwakafanana neheterophilic antibodies kana rheumatoid factor.Tarisa nhoroondo yekurapa kwemurwere uye tsvaga nhoroondo yerheumatoid arthritis.Murabhoritari Mhedzisiro yekuongororwa kweRF factor yaive yakakwira.Mushure mekutaurirana nekiriniki, murwere akataurirwa uye akapa chirevo.Mukuzotevera kunotevera, murwere akange asina zviratidzo zvine chekuita nethrombus uye akatongerwa kuve mhosva yenhema yeD-dimer.
【Kupfupikisa】
D-dimer chiratidzo chakakosha chekuregererwa kusina kunaka kwethrombosis.Iine high senitivity, asi iyo inoenderana chaiyo ichave isina simba.Panewo chimwe chikamu chezvinyorwa zvenhema.Iko kusanganiswa kweD-dimer neFDP kunogona kuderedza chikamu cheD- Kune yenhema yakanaka ye dimer, apo mhedzisiro yerabhoritari inoratidza kuti D-dimer ≥ FDP, mitongo inotevera inogona kuitwa pamhedzisiro yebvunzo:
1. Kana hunhu hwakaderera (
2. Kana chigumisiro chiri chepamusoro (> Kucheka-kubvisa kukosha), ongorora zvinhu zvinokurudzira, panogona kuva nekupindira kwezvinhu.Inokurudzirwa kuita akawanda dilution bvunzo.Kana mhedzisiro iri mutsara, chokwadi chechokwadi chinogoneka.Kana isiri mutsara, zvinyorwa zvenhema.Iwe unogona zvakare kushandisa yechipiri reagent yekusimbisa uye kutaurirana nekiriniki nenguva.
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